Gentamicin Released from Porous Scaffolds Fabricated by Stereolithography

Joint Authors

Channasanon, Somruethai
Udomkusonsri, Pareeya
Chantaweroad, Surapol
Tesavibul, Passakorn
Tanodekaew, Siriporn

Source

Journal of Healthcare Engineering

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-08-20

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Public Health
Medicine

Abstract EN

Porous oligolactide-hydroxyapatite composite scaffolds were obtained by stereolithographic fabrication.

Gentamicin was then coated on the scaffolds afterwards, to achieve antimicrobial delivery ability to treat bone infection.

The scaffolds examined by stereomicroscope, SEM, and μCT-scan showed a well-ordered pore structure with uniform pore distribution and pore interconnectivity.

The physical and mechanical properties of the scaffolds were investigated.

It was shown that not only porosity but also scaffold structure played a critical role in governing the strength of scaffolds.

A good scaffold design could create proper orientation of pores in a way to strengthen the scaffold structure.

The drug delivery profile of the porous scaffolds was also analyzed using microbiological assay.

The release rates of gentamicin from the scaffolds showed prolonged drug release at the levels higher than the minimum inhibitory concentrations for S.

aureus and E.

coli over a 2-week period.

It indicated a potential of the scaffolds to serve as local antibiotic delivery to prevent bacterial infection.

American Psychological Association (APA)

Channasanon, Somruethai& Udomkusonsri, Pareeya& Chantaweroad, Surapol& Tesavibul, Passakorn& Tanodekaew, Siriporn. 2017. Gentamicin Released from Porous Scaffolds Fabricated by Stereolithography. Journal of Healthcare Engineering،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1181425

Modern Language Association (MLA)

Channasanon, Somruethai…[et al.]. Gentamicin Released from Porous Scaffolds Fabricated by Stereolithography. Journal of Healthcare Engineering No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1181425

American Medical Association (AMA)

Channasanon, Somruethai& Udomkusonsri, Pareeya& Chantaweroad, Surapol& Tesavibul, Passakorn& Tanodekaew, Siriporn. Gentamicin Released from Porous Scaffolds Fabricated by Stereolithography. Journal of Healthcare Engineering. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1181425

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1181425