Comparison between the HLA-B∗58 : 01 Allele and Single-Nucleotide Polymorphisms in Chromosome 6 for Prediction of Allopurinol-Induced Severe Cutaneous Adverse Reactions
Joint Authors
Sukasem, Chonlaphat
Saksit, Niwat
Nakkam, Nontaya
Konyoung, Parinya
Khunarkornsiri, Usanee
Tassaneeyakul, Wongwiwat
Chumworathayi, Pansu
Kanjanawart, Sirimas
Sangviroon, Alisara
Pattanacheewapull, Oranuch
Tassaneeyakul, Wichittra
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Severe cutaneous adverse drug reactions (SCARs) are life-threatening reactions.
The strong association between the HLA-B∗58 : 01 allele and allopurinol-induced SCARs is well recognized.
Screening for HLA-B∗58 : 01 allele before prescribing allopurinol in some populations has been recommended.
Several single-nucleotide polymorphisms (SNPs) in chromosome 6 have been found to be tightly linked with the HLA allele, and these SNPs have been proposed as surrogate markers of the HLA-B∗58 : 01 allele.
This study aimed to evaluate the association between three SNPs in chromosome 6 and allopurinol-induced SCARs in a Thai population.
The linkage disequilibrium between the HLA-B∗58 : 01 allele and these SNPs was also evaluated.
Results showed that three SNPs including rs9263726, rs2734583, and rs3099844 were significantly associated with allopurinol-induced SCARs but with a lower degree of association when compared with the HLA-B∗58 : 01 allele.
The sensitivity, specificity, PPV, and NPV of these SNPs were comparable to those of the HLA-B∗58 : 01 allele.
Although detection of the SNP is simpler and less expensive compared with that of the HLA-B∗58 : 01 allele, these SNPs were not perfectly linked with the HLA-B∗58 : 01 allele.
Screening using these SNPs as surrogate markers of the HLA-B∗58 : 01 allele to avoid SCARs prior to allopurinol administration needs caution because of their imperfect linkage with the HLA-B∗58 : 01 allele.
American Psychological Association (APA)
Saksit, Niwat& Nakkam, Nontaya& Konyoung, Parinya& Khunarkornsiri, Usanee& Tassaneeyakul, Wongwiwat& Chumworathayi, Pansu…[et al.]. 2017. Comparison between the HLA-B∗58 : 01 Allele and Single-Nucleotide Polymorphisms in Chromosome 6 for Prediction of Allopurinol-Induced Severe Cutaneous Adverse Reactions. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1181642
Modern Language Association (MLA)
Saksit, Niwat…[et al.]. Comparison between the HLA-B∗58 : 01 Allele and Single-Nucleotide Polymorphisms in Chromosome 6 for Prediction of Allopurinol-Induced Severe Cutaneous Adverse Reactions. Journal of Immunology Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1181642
American Medical Association (AMA)
Saksit, Niwat& Nakkam, Nontaya& Konyoung, Parinya& Khunarkornsiri, Usanee& Tassaneeyakul, Wongwiwat& Chumworathayi, Pansu…[et al.]. Comparison between the HLA-B∗58 : 01 Allele and Single-Nucleotide Polymorphisms in Chromosome 6 for Prediction of Allopurinol-Induced Severe Cutaneous Adverse Reactions. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1181642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181642