The Role of NK Cells in Pig-to-Human Xenotransplantation
Joint Authors
Puga Yung, Gisella
Schneider, Mårten K. J.
Seebach, Jörg D.
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-19
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Recruitment of human NK cells to porcine tissues has been demonstrated in pig organs perfused ex vivo with human blood in the early 1990s.
Subsequently, the molecular mechanisms leading to adhesion and cytotoxicity in human NK cell-porcine endothelial cell (pEC) interactions have been elucidated in vitro to identify targets for therapeutic interventions.
Specific molecular strategies to overcome human anti-pig NK cell responses include (1) blocking of the molecular events leading to recruitment (chemotaxis, adhesion, and transmigration), (2) expression of human MHC class I molecules on pECs that inhibit NK cells, and (3) elimination or blocking of pig ligands for activating human NK receptors.
The potential of cell-based strategies including tolerogenic dendritic cells (DC) and regulatory T cells (Treg) and the latest progress using transgenic pigs genetically modified to reduce xenogeneic NK cell responses are discussed.
Finally, we present the status of phenotypic and functional characterization of nonhuman primate (NHP) NK cells, essential for studying their role in xenograft rejection using preclinical pig-to-NHP models, and summarize key advances and important perspectives for future research.
American Psychological Association (APA)
Puga Yung, Gisella& Schneider, Mårten K. J.& Seebach, Jörg D.. 2017. The Role of NK Cells in Pig-to-Human Xenotransplantation. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1181839
Modern Language Association (MLA)
Puga Yung, Gisella…[et al.]. The Role of NK Cells in Pig-to-Human Xenotransplantation. Journal of Immunology Research No. 2017 (2017), pp.1-19.
https://search.emarefa.net/detail/BIM-1181839
American Medical Association (AMA)
Puga Yung, Gisella& Schneider, Mårten K. J.& Seebach, Jörg D.. The Role of NK Cells in Pig-to-Human Xenotransplantation. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1181839
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181839