IL-1β and IL-6 Are Highly Expressed in RF+IgE+ Systemic Lupus Erythematous Subtype
Joint Authors
Wu, Yongkang
Cai, Bei
Zhang, Junlong
Shen, Beilei
Huang, Zhuochun
Tan, Chunyu
Baan, Carla C.
Wang, Lanlan
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Systemic lupus erythematosus (SLE) is an autoimmune disease with great heterogeneity in pathogenesis and clinical symptoms.
Rheumatoid factor (RF) is one key indicator for rheumatoid arthritis (RA) while immunoglobulin E (IgE) is associated with type I hypersensitivity.
To better categorize SLE subtypes, we determined the dominant cytokines based on familial SLE patients.
Methods.
RF, IgE, and multiple cytokines (i.e., IL-1β, IL-6, IL-8, IL-10, IL-17, IFN-γ, IP-10, MCP-1, and MIP-1β) were measured in sera of familial SLE patients (n=3), noninherited SLE patients (n=108), and healthy controls (n=80).
Results.
Three familial SLE patients and 5 noninherited SLE cases are with features of RF+IgE+.
These RF+IgE+ SLE patients expressed significantly higher levels of IL-1β and IL-6 than the other SLE patients (P<0.05).
IL-6 correlated with both IgE and IL-1β levels in RF+IgE+ SLE patients (r2=0.583, P=0.027; r2=0.847, P=0.001), and IgE also correlated with IL-1β (r2=0.567, P=0.031).
Conclusion.
Both IL-1β and IL-6 are highly expressed cytokines in RF+IgE+ SLE subtype which may be related to the pathogenesis of this special SLE subtype and provide accurate treatment strategy by neutralizing IL-1β and IL-6.
American Psychological Association (APA)
Wu, Yongkang& Cai, Bei& Zhang, Junlong& Shen, Beilei& Huang, Zhuochun& Tan, Chunyu…[et al.]. 2017. IL-1β and IL-6 Are Highly Expressed in RF+IgE+ Systemic Lupus Erythematous Subtype. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1181892
Modern Language Association (MLA)
Wu, Yongkang…[et al.]. IL-1β and IL-6 Are Highly Expressed in RF+IgE+ Systemic Lupus Erythematous Subtype. Journal of Immunology Research No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1181892
American Medical Association (AMA)
Wu, Yongkang& Cai, Bei& Zhang, Junlong& Shen, Beilei& Huang, Zhuochun& Tan, Chunyu…[et al.]. IL-1β and IL-6 Are Highly Expressed in RF+IgE+ Systemic Lupus Erythematous Subtype. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1181892
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181892