Elevated Levels of Interferon-γ Are Associated with High Levels of Epstein-Barr Virus Reactivation in Patients with the Intestinal Type of Gastric Cancer
Joint Authors
Cárdenas-Mondragón, María G.
Torres, Javier
Camorlinga-Ponce, Margarita
Maldonado-Bernal, Carmen
Sánchez-Zauco, Norma
Gómez-Delgado, Alejandro
Fuentes-Pananá, Ezequiel M.
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
The inflammatory response directed against Helicobacter pylori (HP) is believed to be one of the main triggers of the appearance of gastric lesions and their progression to gastric cancer (GC).
Epstein-Barr virus (EBV) has been found responsible for about 10% of all GCs, but the inflammatory response has not been studied in GC patients with evidence of high levels of EBV reactivation.
Objective.
To determine the relationship between inflammation and antibodies against EBV reactivation antigens, HP, and the bacterium virulence factor CagA in patients with GC.
Methods.
127 GC patients, 46 gastritis patients, and 197 healthy subjects were studied.
IL-1β, IL-6, IL-8, IL-10, TNF-α, TGF-β, MCP-1, and IFN-γ levels were measured in serum or plasma and compared against the antibody titers of VCA-IgG, HP, and the HP virulence factor CagA.
Statistical associations were estimated.
Results.
Significant ORs and positive trends were found between VCA-IgG and IFN-γ, specifically for patients with GC of intestinal type (OR: 6.4, 95% C.I.
1.2–35.4) (p<0.044).
Conclusions.
We confirmed a positive association between a marker of EBV reactivation and intestinal gastric cancer and present evidence of a correlation with elevated serum levels of IFN-γ, but not with the other cytokines.
American Psychological Association (APA)
Cárdenas-Mondragón, María G.& Torres, Javier& Sánchez-Zauco, Norma& Gómez-Delgado, Alejandro& Camorlinga-Ponce, Margarita& Maldonado-Bernal, Carmen…[et al.]. 2017. Elevated Levels of Interferon-γ Are Associated with High Levels of Epstein-Barr Virus Reactivation in Patients with the Intestinal Type of Gastric Cancer. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1182058
Modern Language Association (MLA)
Cárdenas-Mondragón, María G.…[et al.]. Elevated Levels of Interferon-γ Are Associated with High Levels of Epstein-Barr Virus Reactivation in Patients with the Intestinal Type of Gastric Cancer. Journal of Immunology Research No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1182058
American Medical Association (AMA)
Cárdenas-Mondragón, María G.& Torres, Javier& Sánchez-Zauco, Norma& Gómez-Delgado, Alejandro& Camorlinga-Ponce, Margarita& Maldonado-Bernal, Carmen…[et al.]. Elevated Levels of Interferon-γ Are Associated with High Levels of Epstein-Barr Virus Reactivation in Patients with the Intestinal Type of Gastric Cancer. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1182058
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182058