Clinical Outcomes of Specific Immunotherapy in Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis

Joint Authors

Chen, Jiang
Xiao-Zhong, Guo
Qi, Xingshun

Source

Journal of Immunology Research

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-02-07

Country of Publication

Egypt

No. of Pages

16

Main Subjects

Biology

Abstract EN

Specific immunotherapies, including vaccines with autologous tumor cells and tumor antigen-specific monoclonal antibodies, are important treatments for PC patients.

To evaluate the clinical outcomes of PC-specific immunotherapy, we performed a systematic review and meta-analysis of the relevant published clinical trials.

The effects of specific immunotherapy were compared with those of nonspecific immunotherapy and the meta-analysis was executed with results regarding the overall survival (OS), immune responses data, and serum cancer markers data.

The pooled analysis was performed by using the random-effects model.

We found that significantly improved OS was noted for PC patients utilizing specific immunotherapy and an improved immune response was also observed.

In conclusion, specific immunotherapy was superior in prolonging the survival time and enhancing immunological responses in PC patients.

American Psychological Association (APA)

Chen, Jiang& Xiao-Zhong, Guo& Qi, Xingshun. 2017. Clinical Outcomes of Specific Immunotherapy in Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1182133

Modern Language Association (MLA)

Chen, Jiang…[et al.]. Clinical Outcomes of Specific Immunotherapy in Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis. Journal of Immunology Research No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1182133

American Medical Association (AMA)

Chen, Jiang& Xiao-Zhong, Guo& Qi, Xingshun. Clinical Outcomes of Specific Immunotherapy in Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1182133

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1182133