Impact of the Polymorphism rs9264942 near the HLA-C Gene on HIV-1 DNA Reservoirs in Asymptomatic Chronically Infected Patients Initiating Antiviral Therapy

Joint Authors

Herráiz-Nicuesa, Laura
Hernández-Flórez, Diana Carolina
Valor, Lara
García-Consuegra, Sonia
Navarro-Valdivieso, Juan Paulo
Fernández-Cruz, Eduardo
Rodríguez-Sainz, Carmen

Source

Journal of Immunology Research

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-12-28

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Biology

Abstract EN

Several genome-wide association studies have identified a polymorphism located 35 kb upstream of the coding region of HLA-C gene (rs9264942; termed −35 C/T) as a host factor significantly associated with the control of HIV-1 viremia in untreated patients.

The potential association of this host genetic polymorphism with the viral reservoirs has never been investigated, nor the association with the viral control in response to the treatment.

In this study, we assess the influence of the polymorphism −35 C/T on the outcome of virus burden in 183 antiretroviral-naïve HIV-1-infected individuals who initiated antiviral treatment (study STIR-2102), analyzing HIV-1 RNA viremia and HIV-1 DNA reservoirs.

The rs9264942 genotyping was investigated retrospectively, and plasma levels of HIV-1 RNA and peripheral blood mononuclear cell- (PBMC-) associated HIV-1 DNA were compared between carriers and noncarriers of the protective allele −35 C before antiretroviral therapy (ART), one month after ART and at the end of the study (36 months).

HIV-1 RNA and HIV-1 DNA levels were both variables significantly different between carriers and noncarriers of the allele −35 C before ART.

HIV-1 DNA levels remained also significantly different one month posttherapy.

However, this protective effect of the −35 C allele was not maintained after long-term ART.

American Psychological Association (APA)

Herráiz-Nicuesa, Laura& Hernández-Flórez, Diana Carolina& Valor, Lara& García-Consuegra, Sonia& Navarro-Valdivieso, Juan Paulo& Fernández-Cruz, Eduardo…[et al.]. 2017. Impact of the Polymorphism rs9264942 near the HLA-C Gene on HIV-1 DNA Reservoirs in Asymptomatic Chronically Infected Patients Initiating Antiviral Therapy. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1182167

Modern Language Association (MLA)

Herráiz-Nicuesa, Laura…[et al.]. Impact of the Polymorphism rs9264942 near the HLA-C Gene on HIV-1 DNA Reservoirs in Asymptomatic Chronically Infected Patients Initiating Antiviral Therapy. Journal of Immunology Research No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1182167

American Medical Association (AMA)

Herráiz-Nicuesa, Laura& Hernández-Flórez, Diana Carolina& Valor, Lara& García-Consuegra, Sonia& Navarro-Valdivieso, Juan Paulo& Fernández-Cruz, Eduardo…[et al.]. Impact of the Polymorphism rs9264942 near the HLA-C Gene on HIV-1 DNA Reservoirs in Asymptomatic Chronically Infected Patients Initiating Antiviral Therapy. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1182167

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1182167