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Getting “Inside” Type I IFNs: Type I IFNs in Intracellular Bacterial Infections
Joint Authors
Snyder, Deann T.
Hedges, Jodi F.
Jutila, Mark A.
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-26
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Type I interferons represent a unique and complex group of cytokines, serving many purposes during innate and adaptive immunity.
Discovered in the context of viral infections, type I IFNs are now known to have myriad effects in infectious and autoimmune disease settings.
Type I IFN signaling during bacterial infections is dependent on many factors including whether the infecting bacterium is intracellular or extracellular, as different signaling pathways are activated.
As such, the repercussions of type I IFN induction can positively or negatively impact the disease outcome.
This review focuses on type I IFN induction and downstream consequences during infection with the following intracellular bacteria: Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tuberculosis, Salmonella enterica serovar Typhimurium, Francisella tularensis, Brucella abortus, Legionella pneumophila, and Coxiella burnetii.
Intracellular bacterial infections are unique because the bacteria must avoid, circumvent, and even co-opt microbial “sensing” mechanisms in order to reside and replicate within a host cell.
Furthermore, life inside a host cell makes intracellular bacteria more difficult to target with antibiotics.
Because type I IFNs are important immune effectors, modulating this pathway may improve disease outcomes.
But first, it is critical to understand the context-dependent effects of the type I IFN pathway in intracellular bacterial infections.
American Psychological Association (APA)
Snyder, Deann T.& Hedges, Jodi F.& Jutila, Mark A.. 2017. Getting “Inside” Type I IFNs: Type I IFNs in Intracellular Bacterial Infections. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1182242
Modern Language Association (MLA)
Snyder, Deann T.…[et al.]. Getting “Inside” Type I IFNs: Type I IFNs in Intracellular Bacterial Infections. Journal of Immunology Research No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1182242
American Medical Association (AMA)
Snyder, Deann T.& Hedges, Jodi F.& Jutila, Mark A.. Getting “Inside” Type I IFNs: Type I IFNs in Intracellular Bacterial Infections. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1182242
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182242