Hypercysteinemia, A Potential Risk Factor for Central Obesity and Related Disorders in Azores, Portugal

Joint Authors

Lima, Ana
Ferin, Rita
Bourbon, Mafalda
Baptista, José
Pavão, M. Leonor

Source

Journal of Nutrition and Metabolism

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-06-20

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Nutrition & Dietetics

Abstract EN

In Azores, the standardized mortality rate for coronary artery disease (CAD) is nearly the double when compared to mainland Portugal.

The aim of this study was to compare the prevalence of conventional CAD risk factors, as well as the plasma aminothiol profile (and its major determinants), between two groups of healthy subjects from Ponta Delgada (in Azores) and Lisbon (in mainland) cities, searching for precocious biomarker(s) of the disease.

The study groups consisted of 101 healthy volunteers from Ponta Delgada (PDL) and 121 from Lisbon, aged 20–69 years.

No differences in the prevalence of classical CAD risk factors were found between the study groups, except in physical inactivity and related central obesity, which were both higher in PDL men than in those from Lisbon.

Hypercysteinemia, which seems to result from sulfur-rich amino acid diets and/or vitamin B12 malabsorption, revealed to be significantly more prevalent in PDL vs.

Lisbon subjects (18% vs.

4%, P=0.001), namely, in male gender.

Moreover, plasma Cys levels predicted waist circumference (β coefficient = 0.102, P=0.032) and concomitant central obesity and were also associated with insulin resistance.

Nevertheless, hyperhomocysteinemia prevalence was similar in both groups, despite the fact that PDL subjects exhibited a higher rate of vitamin B12 deficiency compared to those from Lisbon (19% vs.

6%, P=0.003).

Owing to the nature of this study design, a cause-effect relationship between high plasma Cys levels and central obesity or CAD risk could not be derived, but results strongly suggest that hypercysteinemia is a potential risk factor for metabolic disorders, i.e., obesity and insulin resistance, and CAD in Azores, a hypothesis that asks for confirmation through further large prospective studies.

American Psychological Association (APA)

Lima, Ana& Ferin, Rita& Bourbon, Mafalda& Baptista, José& Pavão, M. Leonor. 2019. Hypercysteinemia, A Potential Risk Factor for Central Obesity and Related Disorders in Azores, Portugal. Journal of Nutrition and Metabolism،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1183549

Modern Language Association (MLA)

Lima, Ana…[et al.]. Hypercysteinemia, A Potential Risk Factor for Central Obesity and Related Disorders in Azores, Portugal. Journal of Nutrition and Metabolism No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1183549

American Medical Association (AMA)

Lima, Ana& Ferin, Rita& Bourbon, Mafalda& Baptista, José& Pavão, M. Leonor. Hypercysteinemia, A Potential Risk Factor for Central Obesity and Related Disorders in Azores, Portugal. Journal of Nutrition and Metabolism. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1183549

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1183549