Hyperuricemia in Children and Adolescents: Present Knowledge and Future Directions
Author
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Recent evidence suggests that hyperuricemia is an important condition in children and adolescents, particularly in association with noncommunicable diseases.
This review aims to summarize our current understanding of this condition in pediatric patients.
An analysis of serum uric acid reference values in a healthy population indicates that they increase gradually with age until adolescence, with differences between the sexes arising at about 12 years of age.
This information should be taken into consideration when defining hyperuricemia in studies.
Gout is extremely rare in children and adolescents, and most patients with gout have an underlying disease.
The major causes of hyperuricemia are chronic conditions, including Down syndrome, metabolic or genetic disease, and congenital heart disease, and acute conditions, including gastroenteritis, bronchial asthma (hypoxia), malignant disorders, and drug side effects.
The mechanisms underlying the associations between these diseases and hyperuricemia are discussed, together with recent genetic information.
Obesity is a major cause of hyperuricemia in otherwise healthy children and adolescents.
Obesity is often accompanied by metabolic syndrome; hyperuricemia in obese children and adolescents is associated with the components of metabolic syndrome and noncommunicable diseases, including hypertension, insulin resistance, dyslipidemia, and chronic kidney disease.
Finally, strategies for the treatment of hyperuricemia, including lifestyle intervention and drug administration, are presented.
American Psychological Association (APA)
Kubota, Masaru. 2019. Hyperuricemia in Children and Adolescents: Present Knowledge and Future Directions. Journal of Nutrition and Metabolism،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1183605
Modern Language Association (MLA)
Kubota, Masaru. Hyperuricemia in Children and Adolescents: Present Knowledge and Future Directions. Journal of Nutrition and Metabolism No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1183605
American Medical Association (AMA)
Kubota, Masaru. Hyperuricemia in Children and Adolescents: Present Knowledge and Future Directions. Journal of Nutrition and Metabolism. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1183605
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183605