Insulin Secretion and Risk for Future Diabetes in Subjects with a Nonpositive Insulinogenic Index
Joint Authors
Oka, Rie
Kometani, Mitsuhiro
Yoshimura, Kenichi
Yoneda, Takashi
Karashima, Shigehiro
Aono, Daisuke
Takeda, Yoshimichi
Takeda, Yoshiyu
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aim.
To characterize subjects with a nonpositive insulinogenic index and longitudinally observe changes in their glucose tolerance.
Subjects and Methods.
A historical cohort study was conducted using data from the medical checkups of public school workers.
Indices of insulin secretion and insulin sensitivity derived from oral glucose tolerance test (OGTT) and the incidences of diabetes and impaired glucose tolerance (IGT) were compared among subgroups of subjects with different insulinogenic index (change in insulin/change in glucose over the first 30 min on the OGTT).
Results.
Of the 1464 nondiabetic subjects at baseline, 72 (4.9%) subjects had a nonpositive insulinogenic index: 42 of those subjects had a nonpositive glucose response (ΔGlu0–30 ≤ 0) and 30 had a nonpositive insulin response (ΔIns0–30 ≤ 0).
Compared with subjects who had normal glucose tolerance (NGT) with insulinogenic index ≥ 0.4, subjects with a nonpositive glucose response had a higher first-phase Stumvoll and lower incidences of diabetes and IGT based on a log-rank test (p<0.05), whereas subjects with a nonpositive insulin response had lower indices of insulin secretion and a higher incidence of diabetes (p<0.05).
Conclusions.
These results demonstrate that in the first 30 min on the OGTT, subjects with a nonpositive insulinogenic index due to a nonpositive glucose response (ΔGlu0–30 ≤ 0) had a lower risk for future diabetes and that subjects with nonpositive insulin response (ΔIns0–30 ≤ 0) had a higher risk for future one.
American Psychological Association (APA)
Aono, Daisuke& Oka, Rie& Kometani, Mitsuhiro& Takeda, Yoshimichi& Karashima, Shigehiro& Yoshimura, Kenichi…[et al.]. 2018. Insulin Secretion and Risk for Future Diabetes in Subjects with a Nonpositive Insulinogenic Index. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1183652
Modern Language Association (MLA)
Aono, Daisuke…[et al.]. Insulin Secretion and Risk for Future Diabetes in Subjects with a Nonpositive Insulinogenic Index. Journal of Diabetes Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1183652
American Medical Association (AMA)
Aono, Daisuke& Oka, Rie& Kometani, Mitsuhiro& Takeda, Yoshimichi& Karashima, Shigehiro& Yoshimura, Kenichi…[et al.]. Insulin Secretion and Risk for Future Diabetes in Subjects with a Nonpositive Insulinogenic Index. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1183652
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183652