The Effects of Morus alba and Acacia catechu on Quality of Life and Overall Function in Adults with Osteoarthritis of the Knee
Joint Authors
Kalman, Douglas S.
Hewlings, Susan J.
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The purpose of this study was to determine the effects of UP1306 on discomfort and function in adults with osteoarthritis of the knee.
In a randomized, double-blinded, placebo-controlled, parallel design, 135 subjects received UP1306, a standardized, proprietary extract of Morus alba and Acacia catechu, glucosamine chondroitin, or placebo for 12 weeks.
Discomfort, stiffness, and activities of daily living measured by the WOMAC questionnaire and VAS (pain/discomfort) were improved within all groups.
Range of motion and distance walked were improved.
There were no changes in TNFα levels for any of the products.
There was a significant difference in urinary C-telopeptides of type II collagen (CTX-II), a marker of cartilage degradation between UP1306, and placebo after 12 weeks (p=0.029).
All efficacy measurements were improved from baseline to most time-points for UP1306, the comparator, and placebo without a significant association between the products.
There was a significant difference between the changes of uCTX-II for UP1306 and placebo after 12 weeks.
Early intervention with UP1306 aimed at reducing bone and cartilage degradation through reported inhibition of catabolic proinflammatory pathways may help to prevent joint cartilage damage.
This study is registered with Clinical Trial ID ISRCTN15418623.
American Psychological Association (APA)
Kalman, Douglas S.& Hewlings, Susan J.. 2017. The Effects of Morus alba and Acacia catechu on Quality of Life and Overall Function in Adults with Osteoarthritis of the Knee. Journal of Nutrition and Metabolism،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1183960
Modern Language Association (MLA)
Kalman, Douglas S.& Hewlings, Susan J.. The Effects of Morus alba and Acacia catechu on Quality of Life and Overall Function in Adults with Osteoarthritis of the Knee. Journal of Nutrition and Metabolism No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1183960
American Medical Association (AMA)
Kalman, Douglas S.& Hewlings, Susan J.. The Effects of Morus alba and Acacia catechu on Quality of Life and Overall Function in Adults with Osteoarthritis of the Knee. Journal of Nutrition and Metabolism. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1183960
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183960