Exercise Training Induced Cardioprotection with Moderate Hyperglycemia versus Sedentary Intensive Glycemic Control in Type 1 Diabetic Rats
Joint Authors
Jiang, Mao
Melling, C. W. James
McDonald, Matthew W.
Dotzert, Michelle S.
Murray, Michael R.
Noble, Earl G.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Intensive insulin therapy (IIT; 4–7 mmol/L) is the preferred treatment for type 1 diabetes mellitus (T1DM) patients to reduce the risk of cardiovascular disease (CVD).
However, this treatment strategy has been questioned as it is accompanied with a sedentary lifestyle leading to weight gain and insulin resistance.
T1DM patients who partake in high-intensity aerobic training (AThigh) to reduce CVD often utilize conventional insulin therapy (CIT; 9–15 mmol/L) to offset the risk of hypoglycemia.
Moreover, exercise modalities incorporating resistance training (RT) have been shown to further reduce this risk.
The purpose of this investigation was twofold: (1) to determine if CIT paired with AThigh results in larger cardioprotection from an ischemia-reperfusion (I-R) injury than IIT and (2) to establish if the integration of RT with AThigh (ART) results in similar cardioprotection as AThigh.
Diabetic (D) male Sprague-Dawley rats were divided into D-IIT (n=12), D-CIT (n=12), D-AThigh (n=8), D-RT (n=8), and D-ART (n=8).
T1DM was induced with streptozotocin, and blood glucose was adjusted with insulin.
D-AThigh occurred on a treadmill (27 m/min; 1 hr), D-RT performed weighted ladder climbs, and D-ART alternated daily between AThigh and RT.
Exercise occurred 5 days/wk for 12 wks.
This investigation demonstrates that cardioprotection following an I-R injury was similar between D-AThigh and D-IIT.
This cardioprotection is not exercise-specific, and each provides unique advantages.
D-AThigh leads to improved glycemia while insulin sensitivity was enhanced following resistance exercises.
Thus, exercise is an effective means to elicit cardioprotection in T1DM.
However, in addition to glycemia, other factors should be considered when tailoring an exercise program for T1DM patients.
American Psychological Association (APA)
McDonald, Matthew W.& Dotzert, Michelle S.& Jiang, Mao& Murray, Michael R.& Noble, Earl G.& Melling, C. W. James. 2018. Exercise Training Induced Cardioprotection with Moderate Hyperglycemia versus Sedentary Intensive Glycemic Control in Type 1 Diabetic Rats. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1183968
Modern Language Association (MLA)
McDonald, Matthew W.…[et al.]. Exercise Training Induced Cardioprotection with Moderate Hyperglycemia versus Sedentary Intensive Glycemic Control in Type 1 Diabetic Rats. Journal of Diabetes Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1183968
American Medical Association (AMA)
McDonald, Matthew W.& Dotzert, Michelle S.& Jiang, Mao& Murray, Michael R.& Noble, Earl G.& Melling, C. W. James. Exercise Training Induced Cardioprotection with Moderate Hyperglycemia versus Sedentary Intensive Glycemic Control in Type 1 Diabetic Rats. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1183968
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183968