Long-Term Effects of Environmental Lead on Erythropoietin Production in Young Adults: A Follow-Up Study of a Prospective Cohort in Kosovo

Joint Authors

Camaj, Pashko R.
Graziano, Joseph H.
Preteni, Emine
Popovac, Dusan
Loiacono, Nancy
Balac, Olgica
Factor-Litvak, Pam

Source

Journal of Environmental and Public Health

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-12-29

Country of Publication

Egypt

No. of Pages

9

Main Topic

Public Health
Medicine

Abstract EN

Background and Aims.

Epidemiologic cross-sectional studies examining the relationship between environmental lead (Pb) exposure and erythropoietin (EPO) production have reported contrasting results.

It is unknown, however, if exposure to Pb earlier in life has an effect on EPO production later in life.

Here, using a prospective study, we evaluate the association between prenatal, early childhood, and concurrent Pb exposure and EPO concentration in young adulthood.

Methods.

From our prospective birth cohort study in Mitrovica (a mining town) and Pristina (a control town), Kosovo, from 1985 to 1998, we located and assessed blood lead concentration (BPb) and serum EPO in 101 participants (mean age 24.9 years) in 2011.

We examined the association between BPb and EPO, stratified by hemoglobin (Hgb), and controlling for potential confounders.

Results.

These results resemble the findings in the original full cohort at 4.5 and 6.5 years of age, at which time we reported that the maintenance of a normal Hgb required increased EPO production among participants exposed to high levels of environmental Pb.

In contrast, when the original cohort was 9.5 and 12 years of age, they were no longer capable of hyper-production of EPO in order to maintain normal levels of Hgb, suggestive of cumulative toxicity to the peritubular cells of the kidney that are responsible for EPO synthesis.

Conclusion.

Our results, along with previously reported findings on this cohort, suggest that a dramatic reduction of Pb exposure may allow for a reversal of the impact that prolonged Pb exposure may have on EPO production.

American Psychological Association (APA)

Camaj, Pashko R.& Graziano, Joseph H.& Preteni, Emine& Popovac, Dusan& Loiacono, Nancy& Balac, Olgica…[et al.]. 2020. Long-Term Effects of Environmental Lead on Erythropoietin Production in Young Adults: A Follow-Up Study of a Prospective Cohort in Kosovo. Journal of Environmental and Public Health،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1184277

Modern Language Association (MLA)

Camaj, Pashko R.…[et al.]. Long-Term Effects of Environmental Lead on Erythropoietin Production in Young Adults: A Follow-Up Study of a Prospective Cohort in Kosovo. Journal of Environmental and Public Health No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1184277

American Medical Association (AMA)

Camaj, Pashko R.& Graziano, Joseph H.& Preteni, Emine& Popovac, Dusan& Loiacono, Nancy& Balac, Olgica…[et al.]. Long-Term Effects of Environmental Lead on Erythropoietin Production in Young Adults: A Follow-Up Study of a Prospective Cohort in Kosovo. Journal of Environmental and Public Health. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1184277

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1184277