Cytoplasmic HAX1 Is an Independent Risk Factor for Breast Cancer Metastasis
Joint Authors
Grzybowska, Ewa A.
Trebinska-Stryjewska, Alicja
Szafron, Lukasz
Rembiszewska, Alina
Wakula, Maciej
Tabor, Sylwia
Sienkiewicz, Renata
Owczarek, Joanna
Balcerak, Anna
Felisiak-Golabek, Anna
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
HAX1 is an antiapoptotic factor involved in the regulation of cell migration and calcium homeostasis, overexpressed in several cancers, including breast cancer.
It has been suggested that HAX1 is also implicated in metastasis.
Herein we report the results of meta-analysis of HAX1 expression, based on publicly available data, which confirms its significant overexpression in breast cancer and demonstrates copy number gain and prognostic value of HAX1 overexpression for metastatic relapse in ER+ tumors.
IHC analysis reported here also reveals its significant overexpression in breast cancer samples from primary tumors, indicating significantly higher HAX1 protein levels in a group of patients who developed distant metastases in a disease course.
Moreover, we demonstrate that HAX1 localization is important for the prediction of metastatic relapse and that cytoplasmic but not nuclear HAX1 is an independent risk factor for breast cancer metastasis.
American Psychological Association (APA)
Trebinska-Stryjewska, Alicja& Szafron, Lukasz& Rembiszewska, Alina& Wakula, Maciej& Tabor, Sylwia& Sienkiewicz, Renata…[et al.]. 2019. Cytoplasmic HAX1 Is an Independent Risk Factor for Breast Cancer Metastasis. Journal of Oncology،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1184433
Modern Language Association (MLA)
Trebinska-Stryjewska, Alicja…[et al.]. Cytoplasmic HAX1 Is an Independent Risk Factor for Breast Cancer Metastasis. Journal of Oncology No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1184433
American Medical Association (AMA)
Trebinska-Stryjewska, Alicja& Szafron, Lukasz& Rembiszewska, Alina& Wakula, Maciej& Tabor, Sylwia& Sienkiewicz, Renata…[et al.]. Cytoplasmic HAX1 Is an Independent Risk Factor for Breast Cancer Metastasis. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1184433
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184433