Γδ T Cell-Based Immunotherapy in Melanoma: State of the Art
Joint Authors
Pirrello, Roberto
Meraviglia, Serena
Dieli, Francesco
Di Stefano, A. B.
Lo Presti, E.
Rinaldi, G.
Fulfaro, F.
Toia, Francesca
Cordova, Adriana
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Metastatic melanoma is still associated with a poor prognosis, and there is increasing interest in immunotherapy alone or in combination with other adjuvant therapies.
Γδ T lymphocytes play a pivot role in the immune response against cancer, but while γδ-based immunotherapy is already a clinical reality for several solid tumors, data on melanoma are still limited and fragmented.
This systematic review presents preclinical and clinical evidence for a role of γδ T lymphocytes in immunotherapeutic strategies for advanced melanoma and discusses research state of the art and future perspectives.
Current strategies focus on in vivo stimulation, and ex vivo adoptive therapy and vaccination; results are promising, but further studies are needed to better investigate the interactions in tumoral microenvironment and to improve clinical efficacy of immunotherapeutic protocols.
American Psychological Association (APA)
Toia, Francesca& Di Stefano, A. B.& Meraviglia, Serena& Lo Presti, E.& Pirrello, Roberto& Rinaldi, G.…[et al.]. 2019. Γδ T Cell-Based Immunotherapy in Melanoma: State of the Art. Journal of Oncology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1184653
Modern Language Association (MLA)
Toia, Francesca…[et al.]. Γδ T Cell-Based Immunotherapy in Melanoma: State of the Art. Journal of Oncology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1184653
American Medical Association (AMA)
Toia, Francesca& Di Stefano, A. B.& Meraviglia, Serena& Lo Presti, E.& Pirrello, Roberto& Rinaldi, G.…[et al.]. Γδ T Cell-Based Immunotherapy in Melanoma: State of the Art. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1184653
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184653