Association between Aqueous Cytokines and Diabetic Retinopathy Stage
Joint Authors
Tao, Yong
Wu, Hailiang
Hwang, De-Kuang
Song, Xudong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
To measure the concentrations of various cytokines in the aqueous humor from patients with different stages of diabetic retinopathy.
Methods.
All selected cataract patients were categorized into 4 groups: the control group (patients without diabetes), nonretinopathy (NDR) group (diabetic patients without retinopathy), nonproliferative diabetic retinopathy (NPDR) group, and proliferative diabetic retinopathy (PDR) group.
The aqueous concentrations of interleukin- (IL-) 1β, IL-2, IL-4, IL-5, IL-6, IL-10, interferon-γ, tumor necrosis factor-α, and vascular endothelial growth factor (VEGF) from patients were measured using the cytometric bead array technique.
Results.
In this study, 10, 22, 15, and 14 patients were included in the control, NDR, NPDR, and PDR groups, respectively.
No difference was observed in the aqueous concentrations of all cytokines between the control group and the NDR group.
By contrast, comparison of these groups revealed that the aqueous concentrations of most inflammatory cytokines were significantly higher in the PDR and NPDR groups.
In addition, the concentrations of IL-2, IL-5, and VEGF were higher in the PDR group than those in the NPDR group.
Conclusions.
Aqueous concentrations of various cytokines increased with the severity of patients’ diabetic retinopathy.
This finding implies that these cytokines might play a role in the progression of diabetic retinopathy.
American Psychological Association (APA)
Wu, Hailiang& Hwang, De-Kuang& Song, Xudong& Tao, Yong. 2017. Association between Aqueous Cytokines and Diabetic Retinopathy Stage. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1185640
Modern Language Association (MLA)
Wu, Hailiang…[et al.]. Association between Aqueous Cytokines and Diabetic Retinopathy Stage. Journal of Ophthalmology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1185640
American Medical Association (AMA)
Wu, Hailiang& Hwang, De-Kuang& Song, Xudong& Tao, Yong. Association between Aqueous Cytokines and Diabetic Retinopathy Stage. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1185640
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1185640