Epstein-Barr Virus as a Promising Immunotherapeutic Target for Nasopharyngeal Carcinoma Treatment
Joint Authors
Teow, Sin-Yeang
Yap, Hooi-Yeen
Peh, Suat Cheng
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Epstein-Barr virus (EBV) is a pathogen that infects more than 90% of global human population.
EBV primarily targets B-lymphocytes and epithelial cells while some of them infect monocyte/macrophage, T-lymphocytes, and dendritic cells (DCs).
EBV infection does not cause death by itself but the infection has been persistently associated with certain type of cancers such as nasopharyngeal carcinoma (NPC), Burkitt’s lymphoma (BL), and Hodgkin’s lymphoma (HL).
Recent findings have shown promise on targeting EBV proteins for cancer therapy by immunotherapeutic approach.
Some studies have also shown the success of adopting EBV-based therapeutic vaccines for the prevention of EBV-associated cancer particularly on NPC.
In-depth investigations are in progress to refine the current therapeutic and vaccination strategies.
In present review, we discuss the highly potential EBV targets for NPC immunotherapy and therapeutic vaccine development as well as addressing the underlying challenges in the process of bringing the therapy and vaccination from the bench to bedside.
American Psychological Association (APA)
Teow, Sin-Yeang& Yap, Hooi-Yeen& Peh, Suat Cheng. 2017. Epstein-Barr Virus as a Promising Immunotherapeutic Target for Nasopharyngeal Carcinoma Treatment. Journal of Pathogens،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1186139
Modern Language Association (MLA)
Teow, Sin-Yeang…[et al.]. Epstein-Barr Virus as a Promising Immunotherapeutic Target for Nasopharyngeal Carcinoma Treatment. Journal of Pathogens No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1186139
American Medical Association (AMA)
Teow, Sin-Yeang& Yap, Hooi-Yeen& Peh, Suat Cheng. Epstein-Barr Virus as a Promising Immunotherapeutic Target for Nasopharyngeal Carcinoma Treatment. Journal of Pathogens. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1186139
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1186139