The Immunotherapeutic Effect of SIRPα-Silenced DCs against Cervical Cancer
Joint Authors
Hu, Bo
Li, Xiaojie
Zhou, Wenying
Liang, Yanlan
Xu, Changzhi
Xie, Zhizhi
Liang, Jiayin
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Signal regulatory protein α (SIRPα), a transmembrane protein that is predominantly expressed in dendritic cells (DCs) or macrophages, interacts with CD47 that is overexpressed in almost all types of tumor cells.
The interaction between SIRPα and CD47 leads to a negative signal that prevents the phenotypic and functional maturation of DC and inhibits phagocytosis.
The SIRPα knockdown in DCs that were pulsed with a modified HPV16E7 (HPV16mE7) protein with enhanced antigenicity and reduced transformation activity results in increased cytokine (TNF-α/IL-12/IL-6) secretion, IFN-γ secretion by T lymphocytes, and in vitro/in vivo tumoricidal activity against cervical cancer cells.
Taken together, these results suggest that SIRPα-silenced DC vaccination presented potential therapeutic implications against cervical cancer.
American Psychological Association (APA)
Li, Xiaojie& Zhou, Wenying& Liang, Yanlan& Xu, Changzhi& Xie, Zhizhi& Liang, Jiayin…[et al.]. 2020. The Immunotherapeutic Effect of SIRPα-Silenced DCs against Cervical Cancer. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1186919
Modern Language Association (MLA)
Li, Xiaojie…[et al.]. The Immunotherapeutic Effect of SIRPα-Silenced DCs against Cervical Cancer. Journal of Immunology Research No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1186919
American Medical Association (AMA)
Li, Xiaojie& Zhou, Wenying& Liang, Yanlan& Xu, Changzhi& Xie, Zhizhi& Liang, Jiayin…[et al.]. The Immunotherapeutic Effect of SIRPα-Silenced DCs against Cervical Cancer. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1186919
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1186919
