Clinical Features and Risk Factors of Active Tuberculosis in Patients with Behçet’s Disease

Joint Authors

Sun, Luxi
Liu, Yaxu
Zhang, Lifan
Zhou, Ziyue
Zhou, Baotong
Liu, Xiaoqing
Zheng, Wenjie

Source

Journal of Immunology Research

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-11-24

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Biology

Abstract EN

To investigate the clinical features and potential risk factors of active tuberculosis (ATB) in Behçet’s disease (BD), we conducted a case-control study on hospitalized BD patients in our institute from 2010 to 2019.

BD patients with ATB were enrolled as the case group.

The control group was selected by random number sampling from the remaining BD patients, including those with latent tuberculosis infection, previous tuberculosis, or without tuberculosis.

Finally, we reviewed 386 BD patients and identified 21 (5.4%) ATB cases, including four (19.0%) microbiologically confirmed and 17 (81.0%) clinically diagnosed.

We found that BD patients with ATB were more prone to have systemic symptoms (fever, night sweating, and unexplained weight loss) and/or symptoms related to the infection site.

Multivariate logistic regression analysis revealed that erythrocyte sedimentation rate ESR>60 mm/h (OR=13.710, 95% CI (1.101, 170.702)), increased IgG (OR=1.226, 95% CI (1.001, 1.502)), and positive T-SPOT.TB (OR=7.793, 95% CI (1.312, 48.464), for 24-200 SFC/106PBMC; OR=17.705 95% CI (2.503, 125.260), for >200 SFC/106PBMC) were potential risk factors for ATB in BD patients.

Our study suggested that when BD patients have systemic symptoms with significantly elevated TB-SPOT, the diagnosis of ATB should be considered.

American Psychological Association (APA)

Liu, Yaxu& Zhang, Lifan& Zhou, Ziyue& Sun, Luxi& Zhou, Baotong& Liu, Xiaoqing…[et al.]. 2020. Clinical Features and Risk Factors of Active Tuberculosis in Patients with Behçet’s Disease. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1187042

Modern Language Association (MLA)

Liu, Yaxu…[et al.]. Clinical Features and Risk Factors of Active Tuberculosis in Patients with Behçet’s Disease. Journal of Immunology Research No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1187042

American Medical Association (AMA)

Liu, Yaxu& Zhang, Lifan& Zhou, Ziyue& Sun, Luxi& Zhou, Baotong& Liu, Xiaoqing…[et al.]. Clinical Features and Risk Factors of Active Tuberculosis in Patients with Behçet’s Disease. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1187042

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1187042