Poly(vinyl alcohol boric acid)-Diclofenac Sodium Salt Drug Delivery Systems: Experimental and Theoretical Studies
Joint Authors
Agop, Maricel
Lupascu, Cristian
Ailincai, Daniela
Dorobanțu, Alexandra Maria
Dima, Bogdan
Irimiciuc, Ștefan Andrei
Olguta, Orzan
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The main aim of the paper was to simulate the drug release by a multifractal theoretical model, as a valuable method to assess the drug release mechanism.
To do this, drug delivery films were prepared by mixing poly(vinyl alcohol boric acid) (PVAB) and diclofenac (DCF) sodium salt drug in different mass ratios from 90/10 to 70/30, in order to obtain drug delivery systems with different releasing rates.
The different drug content of the three systems was confirmed by energy-dispersive spectroscopy (EDAX) analysis, and the encapsulation particularities were investigated by scanning electron microscopy (SEM), atomic force microscopy (AFM), and polarized optical microscopy (POM) techniques.
The ability of the PVAB matrix to anchor the DCF was assessed by Fourier transform infrared (FTIR) spectroscopy.
The in vitro release of the diclofenac sodium salt from the formulations was investigated in biomimetic conditions (pH=7.4 and 37°C) by UV-Vis spectroscopy, measuring the absorbance of the drug at 275 nm and fitting the results on a previously drawn calibration curve.
An estimation of the drug release kinetics was performed by fitting three traditional mathematical models on experimental release data.
Further, the drug delivery was simulated by the fractal theory of motion, in which the release dynamics of the polymer-drug complex system is described through various Riccati-type “regimes.” To explain such dynamics involved multifractal self-modulation in the form of period doubling, quasiperiodicity, intermittency, etc., as well as multifractal self-modulation of network type.
Standard release dynamics were explained by multifractal behaviors of temporary kink type.
The good correlation between the traditional mathematical models and the new proposed theoretical model demonstrated the validity of the multifractal model for the investigation of the drug release.
American Psychological Association (APA)
Ailincai, Daniela& Dorobanțu, Alexandra Maria& Dima, Bogdan& Irimiciuc, Ștefan Andrei& Lupascu, Cristian& Agop, Maricel…[et al.]. 2020. Poly(vinyl alcohol boric acid)-Diclofenac Sodium Salt Drug Delivery Systems: Experimental and Theoretical Studies. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1187116
Modern Language Association (MLA)
Ailincai, Daniela…[et al.]. Poly(vinyl alcohol boric acid)-Diclofenac Sodium Salt Drug Delivery Systems: Experimental and Theoretical Studies. Journal of Immunology Research No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1187116
American Medical Association (AMA)
Ailincai, Daniela& Dorobanțu, Alexandra Maria& Dima, Bogdan& Irimiciuc, Ștefan Andrei& Lupascu, Cristian& Agop, Maricel…[et al.]. Poly(vinyl alcohol boric acid)-Diclofenac Sodium Salt Drug Delivery Systems: Experimental and Theoretical Studies. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1187116
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187116