Salivary IL-17A, IL-17F, and TNF-α Are Associated with Disease Advancement in Patients with Oral and Oropharyngeal Cancer
Joint Authors
Zielińska, Kinga
Karczmarek-Borowska, Bożenna
Kwaśniak, Konrad
Czarnik-Kwaśniak, Justyna
Ludwin, Aleksandra
Lewandowski, Bogumił
Tabarkiewicz, Jacek
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Delayed diagnosis of oral cavity and oropharyngeal cancer is associated with a poor prognosis.
Despite progress in systemic therapy and radiotherapy, there has only been a slight improvement in the five-year survival rate.
A non-invasive diagnostic method that consists of an assessment of specific proteins in saliva samples may significantly facilitate assessment of treatment results in patients diagnosed with oral and oropharyngeal cancer.
The aim of this study was to assess the levels of IL-17 and TNF-α in the saliva of patients with oral and oropharyngeal cancer.
The study was conducted prior to treatment in patients hospitalized in the Frederic Chopin Provincial Specialist Hospital No.
1 in Rzeszów, Poland.
Saliva samples were collected from subjects on an empty stomach.
Cytokine concentrations in the saliva were measured with ELISA and Luminex Multiplex Assays.
The higher salivary concentrations of IL-17A, IL-17F, and TNF-α were significantly associated with disease advancement.
Lower levels of IL-17A were associated with colonization of the oral cavity with aerobic bacteria.
On the other hand, higher concentration of TNF-α was observed in patients with positive aerobic culture of oral swabs.
Our results suggest that IL-17A, IL-17F, and TNF-α measured in the saliva may be a potential biomarker for cancer of the oral cavity and oropharynx.
American Psychological Association (APA)
Zielińska, Kinga& Karczmarek-Borowska, Bożenna& Kwaśniak, Konrad& Czarnik-Kwaśniak, Justyna& Ludwin, Aleksandra& Lewandowski, Bogumił…[et al.]. 2020. Salivary IL-17A, IL-17F, and TNF-α Are Associated with Disease Advancement in Patients with Oral and Oropharyngeal Cancer. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187159
Modern Language Association (MLA)
Zielińska, Kinga…[et al.]. Salivary IL-17A, IL-17F, and TNF-α Are Associated with Disease Advancement in Patients with Oral and Oropharyngeal Cancer. Journal of Immunology Research No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1187159
American Medical Association (AMA)
Zielińska, Kinga& Karczmarek-Borowska, Bożenna& Kwaśniak, Konrad& Czarnik-Kwaśniak, Justyna& Ludwin, Aleksandra& Lewandowski, Bogumił…[et al.]. Salivary IL-17A, IL-17F, and TNF-α Are Associated with Disease Advancement in Patients with Oral and Oropharyngeal Cancer. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187159
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187159