The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy
Joint Authors
Dong, Xuan
Feng, Zhendong
Dai, Haoran
Liu, Fei
Liu, Wenbin
Zhao, Qihan
Tian, Xuefei
Zhang, Na
Huang, Guangrui
Gao, Yu
Liu, Zhiyuan
Dong, Zhaocheng
Zhou, Xiaoshan
Du, Jieli
Liu, Baoli
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Regulatory B cells (Breg) are widely regarded as immunomodulatory cells which play an immunosuppressive role.
Breg inhibits pathological autoimmune response by secreting interleukin-10 (IL-10), transforming growth factor-β (TGF-β), and adenosine and through other ways to prevent T cells and other immune cells from expanding.
Recent studies have shown that different inflammatory environments induce different types of Breg cells, and these different Breg cells have different functions.
For example, Br1 cells can secrete IgG4 to block autoantigens.
Idiopathic membranous nephropathy (IMN) is an autoimmune disease in which the humoral immune response is dominant and the cellular immune response is impaired.
However, only a handful of studies have been done on the role of Bregs in this regard.
In this review, we provide a brief overview of the types and functions of Breg found in human body, as well as the abnormal pathological and immunological phenomena in IMN, and propose the hypothesis that Breg is activated in IMN patients and the proportion of Br1 can be increased.
Our review aims at highlighting the correlation between Breg and IMN and proposes potential mechanisms, which can provide a new direction for the discovery of the pathogenesis of IMN, thus providing a new strategy for the prevention and early treatment of IMN.
American Psychological Association (APA)
Dong, Zhaocheng& Liu, Zhiyuan& Dai, Haoran& Liu, Wenbin& Feng, Zhendong& Zhao, Qihan…[et al.]. 2020. The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1187479
Modern Language Association (MLA)
Dong, Zhaocheng…[et al.]. The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy. Journal of Immunology Research No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1187479
American Medical Association (AMA)
Dong, Zhaocheng& Liu, Zhiyuan& Dai, Haoran& Liu, Wenbin& Feng, Zhendong& Zhao, Qihan…[et al.]. The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1187479
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187479