Association of Neutrophil–Lymphocyte Ratio and the Presence of Neonatal Sepsis
Joint Authors
Xie, Bo
Xu, Zhe
Zhang, Min
Li, Tiewei
Dong, Geng
Hu, Yidi
Wang, Yuewu
Xu, Bangli
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The neutrophil–lymphocyte ratio (NLR) is an emerging risk factor of sepsis that is receiving increasing attention.
However, the relationship between NLR and the presence of sepsis in neonates is poorly studied.
Here, we retrospectively recruited 1480 neonates and collected and analyzed relevant clinical and laboratory data.
According to the International Pediatric Sepsis Consensus, 737 neonates were diagnosed with sepsis, and 555 neonates were suspected for having infection.
Neonates with hyperbilirubinemia (n=188) served as controls.
Neonates with sepsis had significantly elevated neutrophil counts and NLR (P<0.001).
The proportion of neonates with sepsis increased significantly from 41.6% when NLR<0.91 to 66.2% when NLR>1.88 group (P<0.001).
Multiple logistic regression analysis showed that NLR was an independent risk factor for the presence of neonatal sepsis.
Receiver operating characteristic (ROC) curve analysis showed that the optimal cut-off value NLR for predicting the presence of neonatal sepsis was 1.62 (area under curve AUC=0.63, 95% CI 0.60–0.66, P<0.001).
In conclusion, our data suggest that elevated NLR levels are associated with a higher neonatal sepsis risk.
American Psychological Association (APA)
Li, Tiewei& Dong, Geng& Hu, Yidi& Xie, Bo& Wang, Yuewu& Xu, Bangli…[et al.]. 2020. Association of Neutrophil–Lymphocyte Ratio and the Presence of Neonatal Sepsis. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187483
Modern Language Association (MLA)
Hu, Yidi…[et al.]. Association of Neutrophil–Lymphocyte Ratio and the Presence of Neonatal Sepsis. Journal of Immunology Research No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1187483
American Medical Association (AMA)
Li, Tiewei& Dong, Geng& Hu, Yidi& Xie, Bo& Wang, Yuewu& Xu, Bangli…[et al.]. Association of Neutrophil–Lymphocyte Ratio and the Presence of Neonatal Sepsis. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187483