Immunotherapy in the Treatment of Metastatic Melanoma: Current Knowledge and Future Directions
Joint Authors
Greco, A.
Lambiase, Alessandro
Marchetti, Paolo
Botticelli, Andrea
Ralli, Massimo
Visconti, Irene Claudia
Angeletti, Diletta
Fiore, Marco
de Vincentiis, Marco
Source
Journal of Immunology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Melanoma is one of the most immunologic malignancies based on its higher prevalence in immune-compromised patients, the evidence of brisk lymphocytic infiltrates in both primary tumors and metastases, the documented recognition of melanoma antigens by tumor-infiltrating T lymphocytes and, most important, evidence that melanoma responds to immunotherapy.
The use of immunotherapy in the treatment of metastatic melanoma is a relatively late discovery for this malignancy.
Recent studies have shown a significantly higher success rate with combination of immunotherapy and chemotherapy, radiotherapy, or targeted molecular therapy.
Immunotherapy is associated to a panel of dysimmune toxicities called immune-related adverse events that can affect one or more organs and may limit its use.
Future directions in the treatment of metastatic melanoma include immunotherapy with anti-PD1 antibodies or targeted therapy with BRAF and MEK inhibitors.
American Psychological Association (APA)
Ralli, Massimo& Botticelli, Andrea& Visconti, Irene Claudia& Angeletti, Diletta& Fiore, Marco& Marchetti, Paolo…[et al.]. 2020. Immunotherapy in the Treatment of Metastatic Melanoma: Current Knowledge and Future Directions. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1187663
Modern Language Association (MLA)
Ralli, Massimo…[et al.]. Immunotherapy in the Treatment of Metastatic Melanoma: Current Knowledge and Future Directions. Journal of Immunology Research No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1187663
American Medical Association (AMA)
Ralli, Massimo& Botticelli, Andrea& Visconti, Irene Claudia& Angeletti, Diletta& Fiore, Marco& Marchetti, Paolo…[et al.]. Immunotherapy in the Treatment of Metastatic Melanoma: Current Knowledge and Future Directions. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1187663
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187663