Elevated Glucose and Interleukin-1β Differentially Affect Retinal Microglial Cell Proliferation
Joint Authors
Baptista, Filipa I.
Ambrósio, António F.
Aveleira, Célia A.
Castilho, Áurea F.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Diabetic retinopathy is considered a neurovascular disorder, hyperglycemia being considered the main risk factor for this pathology.
Diabetic retinopathy also presents features of a low-grade chronic inflammatory disease, including increased levels of cytokines in the retina, such as interleukin-1 beta (IL-1β).
However, how high glucose and IL-1β affect the different retinal cell types remains to be clarified.
In retinal neural cell cultures, we found that IL-1β and IL-1RI are present in microglia, macroglia, and neurons.
Exposure of retinal neural cell cultures to high glucose upregulated both mRNA and protein levels of IL-1β.
High glucose decreased microglial and macroglial cell proliferation, whereas IL-1β increased their proliferation.
Interestingly, under high glucose condition, although the number of microglial cells decreased, they showed a less ramified morphology, suggesting a more activated state, as supported by the upregulation of the levels of ED-1, a marker of microglia activation.
In conclusion, IL-1β might play a key role in diabetic retinopathy, affecting microglial and macroglial cells and ultimately contributing to neural changes observed in diabetic patients.
Particularly, since IL-1β has an important role in retinal microglia activation and proliferation under diabetes, limiting IL-1β-triggered inflammatory processes may provide a new therapeutic strategy to prevent the progression of diabetic retinopathy.
American Psychological Association (APA)
Baptista, Filipa I.& Aveleira, Célia A.& Castilho, Áurea F.& Ambrósio, António F.. 2017. Elevated Glucose and Interleukin-1β Differentially Affect Retinal Microglial Cell Proliferation. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188324
Modern Language Association (MLA)
Baptista, Filipa I.…[et al.]. Elevated Glucose and Interleukin-1β Differentially Affect Retinal Microglial Cell Proliferation. Mediators of Inflammation No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1188324
American Medical Association (AMA)
Baptista, Filipa I.& Aveleira, Célia A.& Castilho, Áurea F.& Ambrósio, António F.. Elevated Glucose and Interleukin-1β Differentially Affect Retinal Microglial Cell Proliferation. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188324
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188324