Gαq Regulates the Development of Rheumatoid Arthritis by Modulating Th1 Differentiation
Joint Authors
Shi, Guixiu
He, Yan
Wang, Dashan
Zhang, Jiyun
Liu, Yuan
Li, Yan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The Gαq-containing G protein, an important member of G q / 11 class, is ubiquitously expressed in mammalian cells.
Gαq has been found to play an important role in immune regulation and development of autoimmune disease such as rheumatoid arthritis (RA).
However, how Gαq participates in the pathogenesis of RA is still not fully understood.
In the present study, we aimed to find out whether Gαq controls RA via regulation of Th1 differentiation.
We observed that the expression of Gαq was negatively correlated with the expression of signature Th1 cytokine (IFN-γ) in RA patients, which suggests a negative role of Gαq in differentiation of Th1 cells.
By using Gαq knockout (Gnaq−/−) mice, we demonstrated that loss of Gαq led to enhanced Th1 cell differentiation.
Gαq negative regulated the differentiation of Th1 cell by modulating the expression of T-bet and the activity of STAT4.
Furthermore, we detected the increased ratio of Th1 cells in Gnaq−/− bone marrow (BM) chimeras spontaneously developing inflammatory arthritis.
In conclusion, results presented in the study demonstrate that loss of Gαq promotes the differentiation of Th1 cells and contributes to the pathogenesis of RA.
American Psychological Association (APA)
Wang, Dashan& Liu, Yuan& Li, Yan& He, Yan& Zhang, Jiyun& Shi, Guixiu. 2017. Gαq Regulates the Development of Rheumatoid Arthritis by Modulating Th1 Differentiation. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188333
Modern Language Association (MLA)
Wang, Dashan…[et al.]. Gαq Regulates the Development of Rheumatoid Arthritis by Modulating Th1 Differentiation. Mediators of Inflammation No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1188333
American Medical Association (AMA)
Wang, Dashan& Liu, Yuan& Li, Yan& He, Yan& Zhang, Jiyun& Shi, Guixiu. Gαq Regulates the Development of Rheumatoid Arthritis by Modulating Th1 Differentiation. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188333
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188333