Urinary Levels of IL-1β and GDNF in Preterm Neonates as Potential Biomarkers of Motor Development: A Prospective Study
Joint Authors
Vieira, Érica Leandro Marciano
Rocha, Natália Pessoa
Magalhães, Rafael Coelho
Moreira, Janaina Matos
Miranda, Débora Marques
Simões e Silva, Ana Cristina
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objectives.
To evaluate the association between inflammatory biomarkers, neurotrophic factors, birth conditions, and the presence of motor development abnormalities in preterm neonates.
Methods.
Plasma and urinary levels of cytokines (IL-1β, IL-6, IL-10, TNF, and IL-12p70), chemokines (CXCL8/IL-8, CCL2/MCP-1, CCL5/RANTES, CXCL10/IP-10, and CXCL9/MIG), and neurotrophic factors (BDNF and GDNF) were evaluated in 40 preterm neonates born between 28 and 32 incomplete weeks of gestation, at four distinct time points: at birth (umbilical cord blood) (T0), at 48 (T1), at 72 hours (T2), and at 3 weeks after birth (T3).
Biomarkers levels were compared between different time points and then associated with Test of Infant Motor Performance (TIMP) percentiles.
Results.
Maternal age, plasma, and urinary concentrations of inflammatory molecules and neurotrophic factors were significantly different between groups with normal versus lower than expected motor development.
Higher levels of GDNF were found in the group with lower than expected motor development, while IL-1β and CXCL8/IL-8 values were higher in the group with typical motor development.
Conclusion.
Measurements of cytokines and neurotrophic factors in spot urine may be useful in the follow-up of motor development in preterm neonates.
American Psychological Association (APA)
Magalhães, Rafael Coelho& Moreira, Janaina Matos& Vieira, Érica Leandro Marciano& Rocha, Natália Pessoa& Miranda, Débora Marques& Simões e Silva, Ana Cristina. 2017. Urinary Levels of IL-1β and GDNF in Preterm Neonates as Potential Biomarkers of Motor Development: A Prospective Study. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188748
Modern Language Association (MLA)
Magalhães, Rafael Coelho…[et al.]. Urinary Levels of IL-1β and GDNF in Preterm Neonates as Potential Biomarkers of Motor Development: A Prospective Study. Mediators of Inflammation No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1188748
American Medical Association (AMA)
Magalhães, Rafael Coelho& Moreira, Janaina Matos& Vieira, Érica Leandro Marciano& Rocha, Natália Pessoa& Miranda, Débora Marques& Simões e Silva, Ana Cristina. Urinary Levels of IL-1β and GDNF in Preterm Neonates as Potential Biomarkers of Motor Development: A Prospective Study. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188748
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188748