The Interplay between Defensins and Microbiota in Crohn’s Disease
Joint Authors
Coretti, Lorena
Natale, Alessandro
Cuomo, Mariella
Florio, Ermanno
Keller, Simona
Lembo, Francesca
Chiariotti, Lorenzo
Pero, Raffaela
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Crohn’s disease (CD) is a chronic inflammation of the intestinal mucosa, characterized by periods of acute recurrence and remission.
Depending on the specific region affected, CD is classified as ileal CD or colonic CD.
It is largely accepted that the intestinal microbiota is involved in the onset of the pathology.
Indeed, a reduced immune tolerance to components of the intestinal commensal microbiota and inflammation of the intestinal barrier typifies patients with CD.
Several studies have shown defective expression of intestinal antimicrobial peptides (AMPs) in patients with CD compared to controls, particularly defensins.
A reduction in α-defensins is observed in ileal CD, while β-defensins are increased in colonic CD.
In addition to an immunological basis, the disease is frequently associated with genetic alterations including mutations of NOD2 gene.
Several therapeutic strategies to circumvent the dysfunction observed in CD are currently under investigation.
These include the use of delivery systems to administer endogenous AMPs and the engineering of peptidomimetics that could ameliorate the severity of CD.
In this review, the role defensins play in CD and the strategies aimed at overcoming bacterial resistance will be discussed.
American Psychological Association (APA)
Coretti, Lorena& Natale, Alessandro& Cuomo, Mariella& Florio, Ermanno& Keller, Simona& Lembo, Francesca…[et al.]. 2017. The Interplay between Defensins and Microbiota in Crohn’s Disease. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188766
Modern Language Association (MLA)
Coretti, Lorena…[et al.]. The Interplay between Defensins and Microbiota in Crohn’s Disease. Mediators of Inflammation No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1188766
American Medical Association (AMA)
Coretti, Lorena& Natale, Alessandro& Cuomo, Mariella& Florio, Ermanno& Keller, Simona& Lembo, Francesca…[et al.]. The Interplay between Defensins and Microbiota in Crohn’s Disease. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188766
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188766