Fungal Dimorphism and Virulence: Molecular Mechanisms for Temperature Adaptation, Immune Evasion, and In Vivo Survival
Author
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The thermally dimorphic fungi are a unique group of fungi within the Ascomycota phylum that respond to shifts in temperature by converting between hyphae (22–25°C) and yeast (37°C).
This morphologic switch, known as the phase transition, defines the biology and lifestyle of these fungi.
The conversion to yeast within healthy and immunocompromised mammalian hosts is essential for virulence.
In the yeast phase, the thermally dimorphic fungi upregulate genes involved with subverting host immune defenses.
This review highlights the molecular mechanisms governing the phase transition and recent advances in how the phase transition promotes infection.
American Psychological Association (APA)
Gauthier, Gregory M.. 2017. Fungal Dimorphism and Virulence: Molecular Mechanisms for Temperature Adaptation, Immune Evasion, and In Vivo Survival. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188776
Modern Language Association (MLA)
Gauthier, Gregory M.. Fungal Dimorphism and Virulence: Molecular Mechanisms for Temperature Adaptation, Immune Evasion, and In Vivo Survival. Mediators of Inflammation No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1188776
American Medical Association (AMA)
Gauthier, Gregory M.. Fungal Dimorphism and Virulence: Molecular Mechanisms for Temperature Adaptation, Immune Evasion, and In Vivo Survival. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188776
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188776