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Correlation between IL-36α and IL-17 and Activity of the Disease in Selected Autoimmune Blistering Diseases
Joint Authors
Wozniacka, Anna
Szymczak, Izabela
Waszczykowska, Elżbieta
Juczynska, K.
Ociepa, Kamila
Pawliczak, Rafal
Zebrowska, Agnieszka
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Dermatitis herpetiformis (DH), bullous pemphigoid (BP), and pemphigus vulgaris (PV) are autoimmune bullous skin conditions with eosinophilic and neutrophilic infiltrations.
While cytokines are crucial for the affinity and activation of different leukocyte cells in the inflammation and blister formation, there are no studies concerning a role of IL-36.
The goal of the study was to analyze whether interleukin 36 is involved in pathogenesis of DH, BP, and PV.
And the second aim of the study was the estimation of correlation between IL-36 and IL-17 and titers of specific antibodies in these diseases.
Expression of IL-36 and IL-17 was detected in serum in all DH, BP, and PV samples.
Serum levels of IL-36 and IL-17α were statistically higher in DH, BP, and PV groups as compared to the control group.
IL-36α levels were statistically higher in DH patients, as compared to patients with PV and BP.
Our results showed that IL-36 may be helpful in the diagnostic and monitoring of the activity of the disease.
IL-36 may play a relevant role of enrolling eosinophils and neutrophils in DH, BP, and PV and finally provoke tissue injury.
American Psychological Association (APA)
Zebrowska, Agnieszka& Wozniacka, Anna& Juczynska, K.& Ociepa, Kamila& Waszczykowska, Elżbieta& Szymczak, Izabela…[et al.]. 2017. Correlation between IL-36α and IL-17 and Activity of the Disease in Selected Autoimmune Blistering Diseases. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188797
Modern Language Association (MLA)
Zebrowska, Agnieszka…[et al.]. Correlation between IL-36α and IL-17 and Activity of the Disease in Selected Autoimmune Blistering Diseases. Mediators of Inflammation No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1188797
American Medical Association (AMA)
Zebrowska, Agnieszka& Wozniacka, Anna& Juczynska, K.& Ociepa, Kamila& Waszczykowska, Elżbieta& Szymczak, Izabela…[et al.]. Correlation between IL-36α and IL-17 and Activity of the Disease in Selected Autoimmune Blistering Diseases. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188797
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188797