Regular Voluntary Exercise Potentiates Interleukin-1β and Interleukin-18 Secretion by Increasing Caspase-1 Expression in Murine Macrophages
Joint Authors
Sakurai, Takuya
Shirato, Ken
Ohno, Hideki
Imaizumi, Kazuhiko
Ogasawara, Junetsu
Kizaki, Takako
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Moderate-intensity regular exercise improves proinflammatory responses of lipopolysaccharide- (LPS-) stimulated macrophages.
However, intracellular events that mediate the beneficial effects of exercise were unclear.
This study aimed to clarify the mechanism by which regular voluntary exercise (VE) improves proinflammatory cytokine production by macrophages challenged with LPS.
Peritoneal macrophages from VE mice secreted considerably higher amounts of interleukin- (IL-) 1β and IL-18 than did cells from sedentary control (SC) mice in the presence and absence of LPS, although tumor necrosis factor-α and IL-10 secretion were comparable between both groups.
The mRNA levels of these cytokines increased significantly in response to LPS; similar levels were noted in macrophages from both SC and VE mice.
Moreover, LPS evoked similar levels of degradation of inhibitor of κB (IκB) α and phosphorylation of IκB kinase β, c-Jun N-terminal kinase, and p38 in macrophages from SC and VE mice.
These results indicate that the increased IL-1β and IL-18 secretion in VE mice are regulated posttranscriptionally.
On the other hand, macrophages from VE mice showed higher amounts of caspase-1 protein than did cells from SC mice.
These results suggest that regular VE potentiates IL-1β and IL-18 secretion in LPS-challenged macrophages by increasing caspase-1 levels.
American Psychological Association (APA)
Shirato, Ken& Imaizumi, Kazuhiko& Sakurai, Takuya& Ogasawara, Junetsu& Ohno, Hideki& Kizaki, Takako. 2017. Regular Voluntary Exercise Potentiates Interleukin-1β and Interleukin-18 Secretion by Increasing Caspase-1 Expression in Murine Macrophages. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188814
Modern Language Association (MLA)
Shirato, Ken…[et al.]. Regular Voluntary Exercise Potentiates Interleukin-1β and Interleukin-18 Secretion by Increasing Caspase-1 Expression in Murine Macrophages. Mediators of Inflammation No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1188814
American Medical Association (AMA)
Shirato, Ken& Imaizumi, Kazuhiko& Sakurai, Takuya& Ogasawara, Junetsu& Ohno, Hideki& Kizaki, Takako. Regular Voluntary Exercise Potentiates Interleukin-1β and Interleukin-18 Secretion by Increasing Caspase-1 Expression in Murine Macrophages. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188814
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188814