Fixed Regimen Treatment in Unselected Naïve Patients Cohort with Neovascular Age-Related Macular Degeneration
Joint Authors
Casaroli-Marano, Ricardo P.
Bernal-Morales, Carolina
Chamorro-López, Lillian
Dotti-Boada, Marina
Figueroa-Vercellino, Juan P.
Alforja, Socorro
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The current treatment of neovascular age-related macular degeneration (nAMD) generates an excessive care pressure in the public health system.
The search for a satisfactory treatment regimen, whose anatomical and functional stability may be achieved, is a challenge and a goal to be reached.
We analyzed the outcomes in a patient cohort under fixed regimen treatment with intravitreal aflibercept (IVA).
A retrospective study, with at least 1-year follow-up, in consecutive treated unselected naïve patients was carried out.
Standard protocol was performed and evaluated at baseline, month 4 (after loading dose, LD), and month 12 (after fixed bimonthly regimen).
One hundred six patients (123 eyes) aged 80.3 ± 7.7 years were included, receiving 6.8 ± 0.7 IVA.
Visual acuity gain after LD was 5.5 ± 12.0 letters (p<0.0001).
At month 12, 23 eyes (18.7%) gained ≥15 letters and 58 (47.1%) had best-corrected visual acuity ≥20/40 (70 letters).
The improvement in visual acuity was lower in patients with polypoidal choroidal vasculopathy (+4.9 ± 18.1 letters; p = 0.2544) and somewhat higher in patients with retinal angiomatous proliferation (+5.4 ± 12.3 letters; p=0.0373).
Dry macula was present in only 9.8% of cohort at baseline vs.
69.7% at month 12 (p<0.0001).
Atrophy was the most observed complication and related to the elderly patients.
The average of follow-up visits was 3 ± 0.5.
Functional and anatomical improvement were observed with IVA in a fixed bimonthly regimen treatment after LD, with results maintained up to one year with a good compliance.
The fixed bimonthly regimen optimized patient management and logistic issues.
American Psychological Association (APA)
Casaroli-Marano, Ricardo P.& Bernal-Morales, Carolina& Chamorro-López, Lillian& Dotti-Boada, Marina& Figueroa-Vercellino, Juan P.& Alforja, Socorro. 2020. Fixed Regimen Treatment in Unselected Naïve Patients Cohort with Neovascular Age-Related Macular Degeneration. Journal of Ophthalmology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1189805
Modern Language Association (MLA)
Casaroli-Marano, Ricardo P.…[et al.]. Fixed Regimen Treatment in Unselected Naïve Patients Cohort with Neovascular Age-Related Macular Degeneration. Journal of Ophthalmology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1189805
American Medical Association (AMA)
Casaroli-Marano, Ricardo P.& Bernal-Morales, Carolina& Chamorro-López, Lillian& Dotti-Boada, Marina& Figueroa-Vercellino, Juan P.& Alforja, Socorro. Fixed Regimen Treatment in Unselected Naïve Patients Cohort with Neovascular Age-Related Macular Degeneration. Journal of Ophthalmology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1189805
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189805