Can Toxoplasma gondii Pave the Road for Dementia?
Joint Authors
El Saftawy, Enas A.
Amin, Noha M.
Sabry, Rania M.
El-Anwar, Noha
Shash, Rania Y.
Elsebaie, Eman H.
Wassef, Rita M.
Source
Journal of Parasitology Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Dementia is an ominous neurological disease.
Scientists proposed a link between its occurrence and the presence of Toxoplasma gondii (T.
gondii).
The long-term sequels of anti-Toxoplasma premunition, chiefly dominated by TNF-α, on the neurons and their receptors as the insulin-like growth factor-1 receptor (IGF-1R), which is tangled in cognition and synaptic plasticity, are still not clear.
IGF-1R mediates its action via IGF-1, and its depletion is incorporated in the pathogenesis of dementia.
The activated TNF-α signaling pathway induces NF-κβ that may induce or inhibit neurogenesis.
This study speculates the potential impact of anti-Toxoplasma immune response on the expression of IGF-1R in chronic cerebral toxoplasmosis.
The distributive pattern of T.
gondii cysts was studied in association with TNF-α serum levels, the in situ expression of NF-κβ, and IGF-1R in mice using the low virulent ME-49 T.
gondii strain.
There was an elevation of the TNF-α serum level (p value ≤ 0.004) and significant upsurge in NF-κβ whereas IGF-1R was of low abundance (p value < 0.05) compared to the controls.
TNF-α had a strong positive correlation with the intracerebral expression of NF-κβ (r value ≈ 0.943, p value ≈ 0.005) and a strong negative correlation to IGF-1R (r value -0.584 and -0.725 for area% and O.D., respectively).
This activated TNF-α/NF-κβ keeps T.
gondii under control at the expense of IGF-1R expression, depriving neurons of the effect of IGF-1, the receptor’s ligand.
We therefore deduce that T.
gondii immunopathological reaction may be a road paver for developing dementia.
American Psychological Association (APA)
El Saftawy, Enas A.& Amin, Noha M.& Sabry, Rania M.& El-Anwar, Noha& Shash, Rania Y.& Elsebaie, Eman H.…[et al.]. 2020. Can Toxoplasma gondii Pave the Road for Dementia?. Journal of Parasitology Research،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1190131
Modern Language Association (MLA)
El Saftawy, Enas A.…[et al.]. Can Toxoplasma gondii Pave the Road for Dementia?. Journal of Parasitology Research No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1190131
American Medical Association (AMA)
El Saftawy, Enas A.& Amin, Noha M.& Sabry, Rania M.& El-Anwar, Noha& Shash, Rania Y.& Elsebaie, Eman H.…[et al.]. Can Toxoplasma gondii Pave the Road for Dementia?. Journal of Parasitology Research. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1190131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1190131