Conventional DCs from Male and Female Lupus-Prone B6.NZM Sle1Sle2Sle3 Mice Express an IFN Signature and Have a Higher Immunometabolism That Are Enhanced by Estrogen
Joint Authors
Caricchio, Roberto
Chakhtoura, Marita
Sriram, Uma
Gallucci, Stefania
Lee, Michael H.
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-15
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Type I interferons (IFN) are pathogenic in systemic lupus erythematosus (SLE) and were proposed to control the immunometabolism of dendritic cells (DCs).
We previously reported that DCs from female lupus-prone mice constitutively overexpress IFN-responsive genes resembling the IFN signature found in SLE patients.
As SLE has higher incidence in women than men, more so in women of reproductive age, estrogens are suggested to affect lupus pathogenesis.
We investigated the effects of sex and estrogens on the IFN signature in conventional GM-CSF-bone marrow-derived DCs (cDCs), from male and female Triple Congenic B6.NZM.Sle1/Sle2/Sle3 (TCSle) lupus-prone mice or from wild-type C57BL/6 mice, generated with titrations of 17-beta-estradiol (E2).
We found that cDCs from prediseased TCSle male mice express the IFN signature as female TCSle cDCs do.
Estrogens are necessary but not sufficient to express this IFN signature, but high doses of E2 can compensate for other steroidal components.
E2 stimulation, regardless of sex, modulates type I IFN-dependent and type I IFN-independent activation of cDCs in response to TLR stimulation.
Finally, we found that TCSle cDCs from both sexes have elevated markers of immunometabolism and estrogens enhance the metabolic pathways in cDCs, suggesting a mechanistic link between estrogens, immunometabolism, and the IFN signature in lupus.
American Psychological Association (APA)
Lee, Michael H.& Chakhtoura, Marita& Sriram, Uma& Caricchio, Roberto& Gallucci, Stefania. 2018. Conventional DCs from Male and Female Lupus-Prone B6.NZM Sle1Sle2Sle3 Mice Express an IFN Signature and Have a Higher Immunometabolism That Are Enhanced by Estrogen. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-21.
https://search.emarefa.net/detail/BIM-1191642
Modern Language Association (MLA)
Lee, Michael H.…[et al.]. Conventional DCs from Male and Female Lupus-Prone B6.NZM Sle1Sle2Sle3 Mice Express an IFN Signature and Have a Higher Immunometabolism That Are Enhanced by Estrogen. Journal of Immunology Research No. 2018 (2018), pp.1-21.
https://search.emarefa.net/detail/BIM-1191642
American Medical Association (AMA)
Lee, Michael H.& Chakhtoura, Marita& Sriram, Uma& Caricchio, Roberto& Gallucci, Stefania. Conventional DCs from Male and Female Lupus-Prone B6.NZM Sle1Sle2Sle3 Mice Express an IFN Signature and Have a Higher Immunometabolism That Are Enhanced by Estrogen. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-21.
https://search.emarefa.net/detail/BIM-1191642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191642