Conventional DCs from Male and Female Lupus-Prone B6.NZM Sle1Sle2Sle3 Mice Express an IFN Signature and Have a Higher Immunometabolism That Are Enhanced by Estrogen

Joint Authors

Caricchio, Roberto
Chakhtoura, Marita
Sriram, Uma
Gallucci, Stefania
Lee, Michael H.

Source

Journal of Immunology Research

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-21, 21 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-04-15

Country of Publication

Egypt

No. of Pages

21

Main Subjects

Biology

Abstract EN

Type I interferons (IFN) are pathogenic in systemic lupus erythematosus (SLE) and were proposed to control the immunometabolism of dendritic cells (DCs).

We previously reported that DCs from female lupus-prone mice constitutively overexpress IFN-responsive genes resembling the IFN signature found in SLE patients.

As SLE has higher incidence in women than men, more so in women of reproductive age, estrogens are suggested to affect lupus pathogenesis.

We investigated the effects of sex and estrogens on the IFN signature in conventional GM-CSF-bone marrow-derived DCs (cDCs), from male and female Triple Congenic B6.NZM.Sle1/Sle2/Sle3 (TCSle) lupus-prone mice or from wild-type C57BL/6 mice, generated with titrations of 17-beta-estradiol (E2).

We found that cDCs from prediseased TCSle male mice express the IFN signature as female TCSle cDCs do.

Estrogens are necessary but not sufficient to express this IFN signature, but high doses of E2 can compensate for other steroidal components.

E2 stimulation, regardless of sex, modulates type I IFN-dependent and type I IFN-independent activation of cDCs in response to TLR stimulation.

Finally, we found that TCSle cDCs from both sexes have elevated markers of immunometabolism and estrogens enhance the metabolic pathways in cDCs, suggesting a mechanistic link between estrogens, immunometabolism, and the IFN signature in lupus.

American Psychological Association (APA)

Lee, Michael H.& Chakhtoura, Marita& Sriram, Uma& Caricchio, Roberto& Gallucci, Stefania. 2018. Conventional DCs from Male and Female Lupus-Prone B6.NZM Sle1Sle2Sle3 Mice Express an IFN Signature and Have a Higher Immunometabolism That Are Enhanced by Estrogen. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-21.
https://search.emarefa.net/detail/BIM-1191642

Modern Language Association (MLA)

Lee, Michael H.…[et al.]. Conventional DCs from Male and Female Lupus-Prone B6.NZM Sle1Sle2Sle3 Mice Express an IFN Signature and Have a Higher Immunometabolism That Are Enhanced by Estrogen. Journal of Immunology Research No. 2018 (2018), pp.1-21.
https://search.emarefa.net/detail/BIM-1191642

American Medical Association (AMA)

Lee, Michael H.& Chakhtoura, Marita& Sriram, Uma& Caricchio, Roberto& Gallucci, Stefania. Conventional DCs from Male and Female Lupus-Prone B6.NZM Sle1Sle2Sle3 Mice Express an IFN Signature and Have a Higher Immunometabolism That Are Enhanced by Estrogen. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-21.
https://search.emarefa.net/detail/BIM-1191642

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1191642