Acute Neuroinflammatory Response in the Substantia Nigra Pars Compacta of Rats after a Local Injection of Lipopolysaccharide
Joint Authors
Blanco-Alvarez, Victor Manuel
Martinez-Fong, Daniel
Gonzalez-Barrios, Juan Antonio
Flores-Martinez, Yazmin M.
Fernandez-Parrilla, Manuel A.
Ayala-Davila, Jose
Reyes-Corona, David
Soto-Rojas, Luis O.
Luna-Herrera, Claudia
Gutierrez-Castillo, Maria E.
Martínez-Dávila, Irma A.
Leon-Chavez, Bertha Alicia
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-08
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Models of Parkinson’s disease with neurotoxins have shown that microglial activation does not evoke a typical inflammatory response in the substantia nigra, questioning whether neuroinflammation leads to neurodegeneration.
To address this issue, the archetypal inflammatory stimulus, lipopolysaccharide (LPS), was injected into the rat substantia nigra.
LPS induced fever, sickness behavior, and microglial activation (OX42 immunoreactivity), followed by astrocyte activation and leukocyte infiltration (GFAP and CD45 immunoreactivities).
During the acute phase of neuroinflammation, pro- and anti-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-4, and IL-10) responded differentially at mRNA and protein level.
Increased NO production and lipid peroxidation occurred at 168 h after LPS injection.
At this time, evidence of neurodegeneration could be seen, entailing decreased tyrosine hydroxylase (TH) immunoreactivity, irregular body contour, and prolongation discontinuity of TH+ cells, as well as apparent phagocytosis of TH+ cells by OX42+ cells.
Altogether, these results show that LPS evokes a typical inflammatory response in the substantia nigra that is followed by dopaminergic neurodegeneration.
American Psychological Association (APA)
Flores-Martinez, Yazmin M.& Fernandez-Parrilla, Manuel A.& Ayala-Davila, Jose& Reyes-Corona, David& Blanco-Alvarez, Victor Manuel& Soto-Rojas, Luis O.…[et al.]. 2018. Acute Neuroinflammatory Response in the Substantia Nigra Pars Compacta of Rats after a Local Injection of Lipopolysaccharide. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-19.
https://search.emarefa.net/detail/BIM-1191708
Modern Language Association (MLA)
Flores-Martinez, Yazmin M.…[et al.]. Acute Neuroinflammatory Response in the Substantia Nigra Pars Compacta of Rats after a Local Injection of Lipopolysaccharide. Journal of Immunology Research No. 2018 (2018), pp.1-19.
https://search.emarefa.net/detail/BIM-1191708
American Medical Association (AMA)
Flores-Martinez, Yazmin M.& Fernandez-Parrilla, Manuel A.& Ayala-Davila, Jose& Reyes-Corona, David& Blanco-Alvarez, Victor Manuel& Soto-Rojas, Luis O.…[et al.]. Acute Neuroinflammatory Response in the Substantia Nigra Pars Compacta of Rats after a Local Injection of Lipopolysaccharide. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-19.
https://search.emarefa.net/detail/BIM-1191708
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191708