The Change of Systemic Immune-Inflammation Index Independently Predicts Survival of Colorectal Cancer Patients after Curative Resection

Joint Authors

Yang, Hui
Chen, Xiaochen
Guo, Xinwei
Chen, Qingqing
Wu, Haohao
Ji, Shengjun
Zhu, Jiahao
Wang, Wenjie
Gu, Ke

Source

Mediators of Inflammation

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-11-16

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Diseases

Abstract EN

Background.

The systemic immune-inflammation index (SII) has an important role in predicting survival in some solid tumors.

However, little information is available concerning the change of the SII (∆SII) in colorectal cancer (CRC) after curative resection.

This study was designed to evaluate the role of ∆SII in CRC patients who received surgery.

Methods.

A total 206 patients were enrolled in this study.

Clinicopathologic characteristics and survival were assessed.

The relationships between overall survival (OS), disease-free survival (DFS), and ∆SII were analyzed with both univariate Kaplan-Meier and multivariate Cox regression methods.

Results.

Based on the patient data, the receiver operating characteristic (ROC) optimal cutoff value of ∆SII was 127.7 for OS prediction.

The 3-year and 5-year OS rates, respectively, were 60.4% and 36.7% in the high-∆SII group (>127.7) and 87.6% and 79.8% in the low-∆SII group (≤127.7).

The 3-year and 5-year DFS rates, respectively, were 54.1% and 34.1% in the high-∆SII group and 80.3% and 78.5% in the low-∆SII group.

In the univariate analysis, smoking, pathological stages III-IV, high-middle degree of differentiation, lymphatic invasion, vascular invasion, and the high-ΔSII group were associated with poor OS.

Adjuvant therapy, pathological stages III-IV, vascular invasion, and ΔSII were able to predict DFS.

Multivariate analysis revealed that pathological stages III-IV (HR=0.442, 95% CI=0.236-0.827, p=0.011), vascular invasion (HR=2.182, 95% CI=1.243-3.829, p=0.007), and the high-ΔSII group (HR=4.301, 95% CI=2.517-7.350, p<0.001) were independent predictors for OS.

Adjuvant therapy (HR=0.415, 95% CI=0.250-0.687, p=0.001), vascular invasion (HR=3.305, 95% CI=1.944-5.620, p<0.001), and the high-ΔSII group (HR=4.924, 95% CI=2.992-8.102, p<0.001) were significant prognostic factors for DFS.

Conclusions.

The present study demonstrated that ∆SII was associated with the clinical outcome in CRC patients undergoing curative resection, supporting the role of ∆SII as a prognostic biomarker.

American Psychological Association (APA)

Chen, Qingqing& Wu, Haohao& Guo, Xinwei& Gu, Ke& Wang, Wenjie& Chen, Xiaochen…[et al.]. 2020. The Change of Systemic Immune-Inflammation Index Independently Predicts Survival of Colorectal Cancer Patients after Curative Resection. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1191721

Modern Language Association (MLA)

Chen, Qingqing…[et al.]. The Change of Systemic Immune-Inflammation Index Independently Predicts Survival of Colorectal Cancer Patients after Curative Resection. Mediators of Inflammation No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1191721

American Medical Association (AMA)

Chen, Qingqing& Wu, Haohao& Guo, Xinwei& Gu, Ke& Wang, Wenjie& Chen, Xiaochen…[et al.]. The Change of Systemic Immune-Inflammation Index Independently Predicts Survival of Colorectal Cancer Patients after Curative Resection. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1191721

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1191721