Lower FOXP3 mRNA Expression in First-Trimester Decidual Tissue from Uncomplicated Term Pregnancies with a Male Fetus
Joint Authors
Prins, J. R.
Faas, Marijke M.
Kieffer, Tom E. C.
Laskewitz, Anne
Scherjon, Sicco A.
Erwich, Jan Jaap H. M.
Gordijn, Sanne J.
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Pregnancies with a male fetus are associated with higher risks of pregnancy complications through maladaptation of the maternal immune system.
The pathophysiology of this phenomenon is unknown.
A possible pathway could be a fetal sex-dependent maternal immune response, since males have a Y chromosome encoding specific allogenic proteins, possibly contributing to a different response and higher complication risks.
To analyze whether fetal sex affects mRNA expression of maternal immune genes in early pregnancy, real-time PCR quantification was performed in the decidual tissue from primigravid pregnancies (n=20) between 10 and 12 weeks with uncomplicated term outcomes.
Early-pregnancy decidual mRNA expression of the regulatory T-cell marker, FOXP3, was sixfold lower (p<0.01) in pregnancies with a male fetus compared to pregnancies with a female fetus.
Additionally, mRNA expression of IFNγ was sixfold (p<0.05) lower in pregnancies with a male fetus.
The present data imply maternal immunologic differences between pregnancies with male and female fetuses which could be involved in different pregnancy pathophysiologic outcomes.
Moreover, this study indicates that researchers in reproductive immunology should always consider fetal sex bias.
American Psychological Association (APA)
Kieffer, Tom E. C.& Laskewitz, Anne& Faas, Marijke M.& Scherjon, Sicco A.& Erwich, Jan Jaap H. M.& Gordijn, Sanne J.…[et al.]. 2018. Lower FOXP3 mRNA Expression in First-Trimester Decidual Tissue from Uncomplicated Term Pregnancies with a Male Fetus. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1191742
Modern Language Association (MLA)
Kieffer, Tom E. C.…[et al.]. Lower FOXP3 mRNA Expression in First-Trimester Decidual Tissue from Uncomplicated Term Pregnancies with a Male Fetus. Journal of Immunology Research No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1191742
American Medical Association (AMA)
Kieffer, Tom E. C.& Laskewitz, Anne& Faas, Marijke M.& Scherjon, Sicco A.& Erwich, Jan Jaap H. M.& Gordijn, Sanne J.…[et al.]. Lower FOXP3 mRNA Expression in First-Trimester Decidual Tissue from Uncomplicated Term Pregnancies with a Male Fetus. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1191742
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191742