High T3 Induces β-Cell Insulin Resistance via Endoplasmic Reticulum Stress
Joint Authors
Huang, Huibin
Liang, Bo
Liu, Liyun
Li, Liangyi
Zhou, Jingxiong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Hyperthyroidism can cause glucose metabolism disorders and insulin resistance.
Insulin resistance in muscle and adipose tissues has been extensively studied, whereas investigations on β-cell insulin resistance are limited.
This study preliminarily explored the effects of high T3 levels on β-cell line (MIN6) insulin resistance, as well as the roles of endoplasmic reticulum stress (ERS).
In this study, we treated β-cell line with T3, with or without an inhibitor of phosphotyrosine phosphatases (PTPs, sodium vanadate) or ERS inhibitor (4-PBA).
The results indicated that high levels of T3 significantly inhibited insulin secretion in β-cell line.
In addition, we observed an upregulation of p-IRS-1ser307 and downregulation of Akt.
These results can be corrected by sodium vanadate.
Moreover, high T3 levels upregulate the ERS-related proteins PERK, IRE1, ATF6, and GRP78, as well as ERS-related apoptosis CHOP and caspase-12.
Similarly, this change can be corrected by 4-PBA.
These results suggest that high T3 levels can induce insulin resistance in β-cell line by activating ERS and the apoptotic pathway.
American Psychological Association (APA)
Liang, Bo& Liu, Liyun& Huang, Huibin& Li, Liangyi& Zhou, Jingxiong. 2020. High T3 Induces β-Cell Insulin Resistance via Endoplasmic Reticulum Stress. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1191813
Modern Language Association (MLA)
Liang, Bo…[et al.]. High T3 Induces β-Cell Insulin Resistance via Endoplasmic Reticulum Stress. Mediators of Inflammation No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1191813
American Medical Association (AMA)
Liang, Bo& Liu, Liyun& Huang, Huibin& Li, Liangyi& Zhou, Jingxiong. High T3 Induces β-Cell Insulin Resistance via Endoplasmic Reticulum Stress. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1191813
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191813