Role of Chemokine (C–X–C Motif) Ligand 10 (CXCL10) in Renal Diseases
Joint Authors
Chen, Xiangmei
Wu, Lingling
Gao, Jie
Wang, Siyang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-05
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Chemokine C–X–C ligand 10 (CXCL10), also known as interferon-γ-inducible protein 10 (IP-10), exerts biological function mainly through binding to its specific receptor, CXCR3.
Studies have shown that renal resident mesangial cells, renal tubular epithelial cells, podocytes, endothelial cells, and infiltrating inflammatory cells express CXCL10 and CXCR3 under inflammatory conditions.
In the last few years, strong experimental and clinical evidence has indicated that CXCL10 is involved in the development of renal diseases through the chemoattraction of inflammatory cells and facilitation of cell growth and angiostatic effects.
In addition, CXCL10 has been shown to be a significant biomarker of disease severity, and it can be used as a prognostic indicator for a variety of renal diseases, such as renal allograft dysfunction and lupus nephritis.
In this review, we summarize the structures and biological functions of CXCL10 and CXCR3, focusing on the important role of CXCL10 in the pathogenesis of kidney disease, and provide a theoretical basis for CXCL10 as a potential biomarker and therapeutic target in human kidney disease.
American Psychological Association (APA)
Gao, Jie& Wu, Lingling& Wang, Siyang& Chen, Xiangmei. 2020. Role of Chemokine (C–X–C Motif) Ligand 10 (CXCL10) in Renal Diseases. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1191872
Modern Language Association (MLA)
Gao, Jie…[et al.]. Role of Chemokine (C–X–C Motif) Ligand 10 (CXCL10) in Renal Diseases. Mediators of Inflammation No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1191872
American Medical Association (AMA)
Gao, Jie& Wu, Lingling& Wang, Siyang& Chen, Xiangmei. Role of Chemokine (C–X–C Motif) Ligand 10 (CXCL10) in Renal Diseases. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1191872
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191872