Long-Term Outcomes of Behçet’s Syndrome-Related Uveitis: A Monocentric Italian Experience

Abstract EN

Objectives.

To examine demographic and clinical characteristics and long-term visual outcome in a cohort of Italian patients affected by Behçet’s uveitis (BU).

Materials and Methods.

Retrospective chart review of 47 patients with BU attending our unit between January 2018 and December 2019.

Ophthalmologic manifestations, best-corrected visual acuity (BCVA), fluoroangiography and optical coherence tomography findings, and ocular complications were recorded.

Predictive factors of a poor visual outcome and long-term complications were also investigated.

Results.

Forty-seven patients (23 males and 24 females) for a total of 84 eyes were enrolled.

Uveitis was bilateral in 37 (78.7%) patients with panuveitis being the most frequent anatomical pattern (40 out of 84 eyes), whereas 27 eyes presented a posterior uveitis.

Isolated anterior uveitis was detected in 16 eyes.

A significant improvement of median BCVA between baseline and last follow-up values was detected (p=0.042).

A higher risk of poor visual prognosis was observed in patients with uveitis duration greater than 15 years (p=0.019).

A significant resolution of retinal vasculitis was detected between baseline and last follow-up evaluation (p<0.0001) whereas the mean±SD macular thickness did not decrease significantly between baseline (376.00±97.45 μm) and last follow-up evaluation (338.08±55.81 μm).

Forty-two eyes developed 57 complications during the disease course.

Cataract was the most frequent (n=12), followed by epiretinal membranes (n=11) and cystoid macular edema (n=6).

The following variables were identified as predictors of long-term complications: human leukocyte antigen- (HLA-) B51 (p=0.006), panuveitis (p=0.037), and a uveitis duration of more than 15 years (p=0.049).

Conclusions.

In Italian patients, BU typically arises in the third decade and predominantly manifests as a bilateral posterior uveitis or panuveitis.

Its duration is associated with a poor visual prognosis.

Uveitis duration, the presence of HLA-B51, and panuveitis are predictors of long-term structural complications, thus representing main drivers in the treatment decision-making.