Dextromethorphan Suppresses Lipopolysaccharide-Induced Epigenetic Histone Regulation in the Tumor Necrosis Factor-α Expression in Primary Rat Microglia

Joint Authors

Yang, Yu-Chen S. H.
Wu, Pei-Ling
Yang, Yung-Ning
Yang, Chun-Hwa
Kuo, Kuang-Che
Yang, San-Nan

Source

Mediators of Inflammation

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-12-08

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Diseases

Abstract EN

The activation of microglial cells plays an important role in the cascade of events leading to inflammation-mediated neurodegenerative disorders.

Precision therapeutics require that adjunctively feasible drugs be found to prevent microglial cell activation and prevent inflammation-mediated neuronal injury.

Dextromethorphan (DM) has been reported to possess neuroprotective effects in lipopolysaccharide- (LPS-) stimulated animals; however, it remains unclear whether epigenetic regulatory mechanisms in microglial cells are involved in such DM-mediated neuroprotective effects.

In this study, DM simultaneously suppressed LPS-induced activation of tumor necrosis factor- (TNF-) α expression and subsequent caspase-3 signaling in primary microglial cells associated with notable morphological changes.

Furthermore, therapeutic action sites of DM involved differential enhanced trimethylation of H3K4 modifications in the promoter region of tnf-α gene locus in primary microglial cells.

In summary, DM may exert neuroprotective and anti-inflammatory effects through differential epigenetic histone modifications of TNF-α expression in microglial cells and might therefore raise the possibility of providing an adjunctively beneficial role for a tentative therapeutic strategy in neurodegenerative diseases resulting from inflammation.

American Psychological Association (APA)

Yang, Yung-Ning& Yang, Yu-Chen S. H.& Wu, Pei-Ling& Yang, Chun-Hwa& Kuo, Kuang-Che& Yang, San-Nan. 2020. Dextromethorphan Suppresses Lipopolysaccharide-Induced Epigenetic Histone Regulation in the Tumor Necrosis Factor-α Expression in Primary Rat Microglia. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1192243

Modern Language Association (MLA)

Yang, Yung-Ning…[et al.]. Dextromethorphan Suppresses Lipopolysaccharide-Induced Epigenetic Histone Regulation in the Tumor Necrosis Factor-α Expression in Primary Rat Microglia. Mediators of Inflammation No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1192243

American Medical Association (AMA)

Yang, Yung-Ning& Yang, Yu-Chen S. H.& Wu, Pei-Ling& Yang, Chun-Hwa& Kuo, Kuang-Che& Yang, San-Nan. Dextromethorphan Suppresses Lipopolysaccharide-Induced Epigenetic Histone Regulation in the Tumor Necrosis Factor-α Expression in Primary Rat Microglia. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1192243

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1192243