Dextromethorphan Suppresses Lipopolysaccharide-Induced Epigenetic Histone Regulation in the Tumor Necrosis Factor-α Expression in Primary Rat Microglia
Joint Authors
Yang, Yu-Chen S. H.
Wu, Pei-Ling
Yang, Yung-Ning
Yang, Chun-Hwa
Kuo, Kuang-Che
Yang, San-Nan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The activation of microglial cells plays an important role in the cascade of events leading to inflammation-mediated neurodegenerative disorders.
Precision therapeutics require that adjunctively feasible drugs be found to prevent microglial cell activation and prevent inflammation-mediated neuronal injury.
Dextromethorphan (DM) has been reported to possess neuroprotective effects in lipopolysaccharide- (LPS-) stimulated animals; however, it remains unclear whether epigenetic regulatory mechanisms in microglial cells are involved in such DM-mediated neuroprotective effects.
In this study, DM simultaneously suppressed LPS-induced activation of tumor necrosis factor- (TNF-) α expression and subsequent caspase-3 signaling in primary microglial cells associated with notable morphological changes.
Furthermore, therapeutic action sites of DM involved differential enhanced trimethylation of H3K4 modifications in the promoter region of tnf-α gene locus in primary microglial cells.
In summary, DM may exert neuroprotective and anti-inflammatory effects through differential epigenetic histone modifications of TNF-α expression in microglial cells and might therefore raise the possibility of providing an adjunctively beneficial role for a tentative therapeutic strategy in neurodegenerative diseases resulting from inflammation.
American Psychological Association (APA)
Yang, Yung-Ning& Yang, Yu-Chen S. H.& Wu, Pei-Ling& Yang, Chun-Hwa& Kuo, Kuang-Che& Yang, San-Nan. 2020. Dextromethorphan Suppresses Lipopolysaccharide-Induced Epigenetic Histone Regulation in the Tumor Necrosis Factor-α Expression in Primary Rat Microglia. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1192243
Modern Language Association (MLA)
Yang, Yung-Ning…[et al.]. Dextromethorphan Suppresses Lipopolysaccharide-Induced Epigenetic Histone Regulation in the Tumor Necrosis Factor-α Expression in Primary Rat Microglia. Mediators of Inflammation No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1192243
American Medical Association (AMA)
Yang, Yung-Ning& Yang, Yu-Chen S. H.& Wu, Pei-Ling& Yang, Chun-Hwa& Kuo, Kuang-Che& Yang, San-Nan. Dextromethorphan Suppresses Lipopolysaccharide-Induced Epigenetic Histone Regulation in the Tumor Necrosis Factor-α Expression in Primary Rat Microglia. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1192243
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192243