Tag7 (PGLYRP1)‎ Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity

Joint Authors

Sharapova, T. N.
Romanova, E. A.
Sashchenko, L. P.
Yashin, D. V.

Source

Journal of Immunology Research

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-04-11

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Biology

Abstract EN

We have shown that in the human peripheral blood cells, the innate immunity protein Tag7 can activate a subpopulation of CD3+CD4+CD25+ cells, which have antitumor activity.

These cells can induce lysis of HLA-negative tumor cell lines.

The Hsp70 stress molecule on the surface of the tumor cells is used as a recognition target, while the Tag7 protein on the lymphocyte membrane acts as a receptor for Hsp70.

We have also demonstrated that this subpopulation of the CD4+CD25+ cells is CD127 positive and hence is not the Treg cells.

Our data suggest that this subpopulation of cells is identical to the CD4+CD25+ lymphocytes, which are activated in the leukocyte pool by the IL-2 cytokine.

American Psychological Association (APA)

Sharapova, T. N.& Romanova, E. A.& Sashchenko, L. P.& Yashin, D. V.. 2018. Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1192334

Modern Language Association (MLA)

Sharapova, T. N.…[et al.]. Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity. Journal of Immunology Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1192334

American Medical Association (AMA)

Sharapova, T. N.& Romanova, E. A.& Sashchenko, L. P.& Yashin, D. V.. Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1192334

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1192334