Antithyroid Peroxidase Antibodies in Multinodular Hashimoto’s Thyroiditis Indicate a Variant Etiology
Joint Authors
Mehanathan, Pabithadevi B.
Erusan, R. Raskin
Shantaraman, K.
Kannan, S. M.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Hashimoto’s thyroiditis (HT) is a common autoimmune thyroid disorder, which predominantly presents as a diffuse goiter, with few studies which report HT presenting as multinodular goiter, with variable frequencies ranging from 59% to 78.6% especially from south Indian populations.
This variant clinical presentation may have diagnostic challenges which require further analysis.
Anti-TPO antibodies are more common (90-95%) in Hashimoto’s thyroiditis than anti-TG antibodies in Hashimoto’s thyroiditis.
This study analyzes the clinical features and the correlation of anti-TPO levels with diffuse and multinodular forms of HT.
Material and Methods.
This study was conducted in the Department of General Surgery in a tertiary care hospital in south Tamil Nadu.
Patients presenting with clinical features of a thyroid disorder were interviewed and given a detailed clinical, radiological examination and guided FNAC.
Those patients diagnosed by FNAC as HT were registered and a sample of 3cc of blood was drawn for T3, T4, TSH, and anti-TPO analysis.
All the data were tabulated.
Results and Discussion.
Of the 212 patients who presented with goiters, 96 were diagnosed by FNAC as having a cytological picture suggestive of Hashimoto’s thyroiditis.
Of these 96 patients with HT, 46 (47.9%) were multinodular (HT-MNG), 14 (14.58%) were solitary nodules (HT-SNT), and the remaining 36 (37.5%) were diffuse goiters (HT-D).
Of the 46 patients who are HT-MNG, 36.9% had elevated anti-TPO-Ab (more than 35.0U/l) and 63.1% had normal/lower values (less than 35.0U/l).
But of 36 patients with HT-D, 77.7% had elevated anti-TPO-Ab levels (>35U/l).
Chi square statistics was 15.8346 and the p value is 0.0005 (<.05).
Eight cases of HT-D and 3 cases of HT-MNG had hyperthyroidism and 3 cases of HT-D had hypothyroidism and all other cases were in euthyroid state.
Conclusion.
Patients presenting as multinodular Hashimoto’s thyroiditis have low prevalence of elevated anti-TPO-Ab than diffuse HT which suggests that multinodular form of Hashimoto’s thyroiditis is a unique clinical entity with etiopathogenesis that is at variance with the diffuse form.
American Psychological Association (APA)
Mehanathan, Pabithadevi B.& Erusan, R. Raskin& Shantaraman, K.& Kannan, S. M.. 2019. Antithyroid Peroxidase Antibodies in Multinodular Hashimoto’s Thyroiditis Indicate a Variant Etiology. Journal of Thyroid Research،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1192432
Modern Language Association (MLA)
Mehanathan, Pabithadevi B.…[et al.]. Antithyroid Peroxidase Antibodies in Multinodular Hashimoto’s Thyroiditis Indicate a Variant Etiology. Journal of Thyroid Research No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1192432
American Medical Association (AMA)
Mehanathan, Pabithadevi B.& Erusan, R. Raskin& Shantaraman, K.& Kannan, S. M.. Antithyroid Peroxidase Antibodies in Multinodular Hashimoto’s Thyroiditis Indicate a Variant Etiology. Journal of Thyroid Research. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1192432
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192432