Comment on “New Alternatives for Autoimmune Disease Treatments: Physicochemical and Clinical Comparability of Biosimilar Etanercept”
Joint Authors
Hassett, Brian
Vicik, Steven
Fitzpatrick, Brian
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-30
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
In their publication, Miranda-Hernandez et al.
2016 [1] present data on the physicochemical and biological comparability of Infinitam® with the reference etanercept innovator product, Enbrel®.
As part of a physicochemical similarity exercise (not comparability), the authors present data on glycan microheterogeneity using hydrophilic interaction ultra-performance-liquid-chromatography (HILIC-UPLC) on three batches of Enbrel and one batch of Infinitam (Figure 3 panel b of Miranda-Hernandez et al.).
We have presented a reproduction of Figure 3 panel b as Figure 1, and, for clarity, have labelled each chromatogram (a–d) (top to bottom).
Miranda-Hernandez et al.
present the top two and the bottom chromatograms as different batches of Enbrel (Figures 1(a), 1(b), and 1(d)).
The third chromatogram (Figure 1(c)) is presented as one batch of Infinitam.
We found the results in chromatogram a to be inconsistent with historical Enbrel manufacturing experience.
American Psychological Association (APA)
Hassett, Brian& Vicik, Steven& Fitzpatrick, Brian. 2018. Comment on “New Alternatives for Autoimmune Disease Treatments: Physicochemical and Clinical Comparability of Biosimilar Etanercept”. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1192452
Modern Language Association (MLA)
Hassett, Brian…[et al.]. Comment on “New Alternatives for Autoimmune Disease Treatments: Physicochemical and Clinical Comparability of Biosimilar Etanercept”. Journal of Immunology Research No. 2018 (2018), pp.1-3.
https://search.emarefa.net/detail/BIM-1192452
American Medical Association (AMA)
Hassett, Brian& Vicik, Steven& Fitzpatrick, Brian. Comment on “New Alternatives for Autoimmune Disease Treatments: Physicochemical and Clinical Comparability of Biosimilar Etanercept”. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1192452
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192452