Comment on “New Alternatives for Autoimmune Disease Treatments: Physicochemical and Clinical Comparability of Biosimilar Etanercept”

Joint Authors

Hassett, Brian
Vicik, Steven
Fitzpatrick, Brian

Source

Journal of Immunology Research

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-3, 3 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-01-30

Country of Publication

Egypt

No. of Pages

3

Main Subjects

Biology

Abstract EN

In their publication, Miranda-Hernandez et al.

2016 [1] present data on the physicochemical and biological comparability of Infinitam® with the reference etanercept innovator product, Enbrel®.

As part of a physicochemical similarity exercise (not comparability), the authors present data on glycan microheterogeneity using hydrophilic interaction ultra-performance-liquid-chromatography (HILIC-UPLC) on three batches of Enbrel and one batch of Infinitam (Figure 3 panel b of Miranda-Hernandez et al.).

We have presented a reproduction of Figure 3 panel b as Figure 1, and, for clarity, have labelled each chromatogram (a–d) (top to bottom).

Miranda-Hernandez et al.

present the top two and the bottom chromatograms as different batches of Enbrel (Figures 1(a), 1(b), and 1(d)).

The third chromatogram (Figure 1(c)) is presented as one batch of Infinitam.

We found the results in chromatogram a to be inconsistent with historical Enbrel manufacturing experience.

American Psychological Association (APA)

Hassett, Brian& Vicik, Steven& Fitzpatrick, Brian. 2018. Comment on “New Alternatives for Autoimmune Disease Treatments: Physicochemical and Clinical Comparability of Biosimilar Etanercept”. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1192452

Modern Language Association (MLA)

Hassett, Brian…[et al.]. Comment on “New Alternatives for Autoimmune Disease Treatments: Physicochemical and Clinical Comparability of Biosimilar Etanercept”. Journal of Immunology Research No. 2018 (2018), pp.1-3.
https://search.emarefa.net/detail/BIM-1192452

American Medical Association (AMA)

Hassett, Brian& Vicik, Steven& Fitzpatrick, Brian. Comment on “New Alternatives for Autoimmune Disease Treatments: Physicochemical and Clinical Comparability of Biosimilar Etanercept”. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1192452

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1192452