Protective Role of γδ T Cells in Different Pathogen Infections and Its Potential Clinical Application
Joint Authors
Wu, Xu
Zhao, Yueshui
Lin, Ling
Xiao, Zhangang
Li, Mingxing
Li, Wanping
Li, Xiaobing
Zhao, Qijie
Wu, Yuanlin
Zhang, Hanyu
Yin, Jianhua
Zhang, Lingling
Shen, Jing
Cho, Chi Hin
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-10
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
γδ T cells, a subgroup of T cells based on the γδ TCR, when compared with conventional T cells (αβ T cells), make up a very small proportion of T cells.
However, its various subgroups are widely distributed in different parts of the human body and are attractive effectors for infectious disease immunity.
γδ T cells are activated and expanded by nonpeptidic antigens (P-Ags), major histocompatibility complex (MHC) molecules, and lipids which are associated with different kinds of pathogen infections.
Activation and proliferation of γδ T cells play a significant role in diverse infectious diseases induced by viruses, bacteria, and parasites and exert their potential effector function to effectively eliminate infection.
It is well known that many types of infectious diseases are detrimental to human life and health and give rise to high incidence of illnesses and death rate all over the world.
To date, there is no comprehensive understanding of the correlation between γδ T cells and infectious diseases.
In this review, we will focus on the various subgroups of γδ T cells (mainly Vδ1 T cells and Vδ2 T cells) which can induce multiple immune responses or effective functions to fight against common pathogen infections, such as Mycobacterium tuberculosis, Listeria monocytogenes, influenza viruses, HIV, EBV, and HBV.
Hopefully, the gamma-delta T cell study will provide a novel effective way to treat infectious diseases.
American Psychological Association (APA)
Zhao, Yueshui& Lin, Ling& Xiao, Zhangang& Li, Mingxing& Wu, Xu& Li, Wanping…[et al.]. 2018. Protective Role of γδ T Cells in Different Pathogen Infections and Its Potential Clinical Application. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1192467
Modern Language Association (MLA)
Zhao, Yueshui…[et al.]. Protective Role of γδ T Cells in Different Pathogen Infections and Its Potential Clinical Application. Journal of Immunology Research No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1192467
American Medical Association (AMA)
Zhao, Yueshui& Lin, Ling& Xiao, Zhangang& Li, Mingxing& Wu, Xu& Li, Wanping…[et al.]. Protective Role of γδ T Cells in Different Pathogen Infections and Its Potential Clinical Application. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1192467
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192467