Lung Interstitial Macrophages: Past, Present, and Future

Joint Authors

Schyns, Joey
Bureau, Fabrice
Marichal, Thomas

Source

Journal of Immunology Research

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-04-30

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Biology

Abstract EN

For a long time, investigations about the lung myeloid compartment have been mainly limited to the macrophages located within the airways, that is, the well-known alveolar macrophages specialized in recycling of surfactant molecules and removal of debris.

However, a growing number of reports have highlighted the complexity of the lung myeloid compartment, which also encompass different subsets of dendritic cells, tissue monocytes, and nonalveolar macrophages, called interstitial macrophages (IM).

Recent evidence supports that, in mice, IM perform important immune functions, including the maintenance of lung homeostasis and prevention of immune-mediated allergic airway inflammation.

In this article, we describe lung IM from a historical perspective and we review current knowledge on their characteristics, ontogeny, and functions, mostly in rodents.

Finally, we emphasize some important future challenges for the field.

American Psychological Association (APA)

Schyns, Joey& Bureau, Fabrice& Marichal, Thomas. 2018. Lung Interstitial Macrophages: Past, Present, and Future. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192482

Modern Language Association (MLA)

Schyns, Joey…[et al.]. Lung Interstitial Macrophages: Past, Present, and Future. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1192482

American Medical Association (AMA)

Schyns, Joey& Bureau, Fabrice& Marichal, Thomas. Lung Interstitial Macrophages: Past, Present, and Future. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192482

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1192482