Biomarkers of Inflammation in Obesity-Psoriatic Patients
Joint Authors
Rodriguez-Cerdeira, Carmen
Carnero Gregorio, Miguel
López-Barcenas, Adriana
Sinani, Ardiana
Cordeiro-Rodríguez, Mónica
Martínez-Herrera, Erick
González-Cespón, José Luís
Fabbrocini, Gabriella
Arenas, R.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-28
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Psoriasis is a common chronic inflammatory multisystemic disease with a complex pathogenesis consisting of genetic, immunological, and environmental components.
It is associated with a number of comorbidities, including diabetes, metabolic syndrome, obesity, and myocardial infarction.
In addition, the severity of psoriasis seems to be related to the severity of obesity.
Patients with higher levels of obesity show poorer response to systemic treatments of psoriasis.
Several studies have demonstrated that white adipose tissue is a crucial site of the formation of proinflammatory adipokines such as leptin, adiponectin, and resistin and classical cytokines such as interleukin- (IL-) 6 and tumour necrosis factor-α.
In psoriasis, due to the proliferation of Th1, Th17, and Th22 cells, IL-22, among others, is produced in addition to the abovementioned cytokines.
With respect to leptin and resistin, both of these adipokines are present in high levels in obese persons with psoriasis.
Further, the plasma levels of leptin and resistin are related to the severity of psoriasis.
These results strongly suggest that obesity, through proinflammatory pathways, is a predisposing factor to the development of psoriasis and that obesity aggravates existing psoriasis.
Different inflammatory biomarkers link psoriasis and obesity.
In this paper, the most important ones are described.
American Psychological Association (APA)
Rodriguez-Cerdeira, Carmen& Cordeiro-Rodríguez, Mónica& Carnero Gregorio, Miguel& López-Barcenas, Adriana& Martínez-Herrera, Erick& Fabbrocini, Gabriella…[et al.]. 2019. Biomarkers of Inflammation in Obesity-Psoriatic Patients. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1193264
Modern Language Association (MLA)
Rodriguez-Cerdeira, Carmen…[et al.]. Biomarkers of Inflammation in Obesity-Psoriatic Patients. Mediators of Inflammation No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1193264
American Medical Association (AMA)
Rodriguez-Cerdeira, Carmen& Cordeiro-Rodríguez, Mónica& Carnero Gregorio, Miguel& López-Barcenas, Adriana& Martínez-Herrera, Erick& Fabbrocini, Gabriella…[et al.]. Biomarkers of Inflammation in Obesity-Psoriatic Patients. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1193264
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193264