The Interplay between Immune System and Microbiota in Diabetes
Joint Authors
Moffa, Simona
Mezza, Teresa
Cefalo, Chiara M. A.
Impronta, Flavia
Sorice, Gian Pio
Santoro, Antonio
Di Giuseppe, Gianfranco
Giaccari, Andrea
Cinti, Francesca
Pontecorvi, Alfredo
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetes is not a single and homogeneous disease, but a cluster of metabolic diseases characterized by the common feature of hyperglycemia.
The pathogenesis of type 1 diabetes (T1D) and type 2 diabetes (T2D) (and all other intermediate forms of diabetes) involves the immune system, in terms of inflammation and autoimmunity.
The past decades have seen an increase in all types of diabetes, accompanied by changes in eating habits and consequently a structural evolution of gut microbiota.
It is likely that all these events could be related and that gut microbiota alterations might be involved in the immunomodulation of diabetes.
Thus, gut microbiota seems to have a direct, even causative role in mediating connections between the environment, food intake, and chronic disease.
As many conditions that increase the risk of diabetes modulate gut microbiota composition, it is likely that immune-mediated reactions, induced by alterations in the composition of the microbiota, can act as facilitators for the onset of diabetes in predisposed subjects.
In this review, we summarize recent evidence in the field of gut microbiota and the role of the latter in modulating the immune reactions involved in the pathogenesis of diabetes.
American Psychological Association (APA)
Moffa, Simona& Mezza, Teresa& Cefalo, Chiara M. A.& Cinti, Francesca& Impronta, Flavia& Sorice, Gian Pio…[et al.]. 2019. The Interplay between Immune System and Microbiota in Diabetes. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1193640
Modern Language Association (MLA)
Moffa, Simona…[et al.]. The Interplay between Immune System and Microbiota in Diabetes. Mediators of Inflammation No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1193640
American Medical Association (AMA)
Moffa, Simona& Mezza, Teresa& Cefalo, Chiara M. A.& Cinti, Francesca& Impronta, Flavia& Sorice, Gian Pio…[et al.]. The Interplay between Immune System and Microbiota in Diabetes. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1193640
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193640