Ginger Oleoresin Alleviated γ-Ray Irradiation-Induced Reactive Oxygen Species via the Nrf2 Protective Response in Human Mesenchymal Stem Cells
Joint Authors
Wang, Jinhan
Fang, Lianying
Zhao, Hui
Liu, Qiang
Ji, Kaihua
Li, Qing
Shi, Yang
Xu, Chang
Wang, Yan
Du, Liqing
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Unplanned exposure to radiation can cause side effects on high-risk individuals; meanwhile, radiotherapies can also cause injury on normal cells and tissues surrounding the tumor.
Besides the direct radiation damage, most of the ionizing radiation- (IR-) induced injuries were caused by generation of reactive oxygen species (ROS).
Human mesenchymal stem cells (hMSCs), which possess self-renew and multilineage differentiation capabilities, are a critical population of cells to participate in the regeneration of IR-damaged tissues.
Therefore, it is imperative to search effective radioprotectors for hMSCs.
This study was to demonstrate whether natural source ginger oleoresin would mitigate IR-induced injuries in human mesenchymal stem cells (hMSCs).
We demonstrated that ginger oleoresin could significantly reduce IR-induced cytotoxicity, ROS generation, and DNA strand breaks.
In addition, the ROS-scavenging mechanism of ginger oleoresin was also investigated.
The results showed that ginger oleoresin could induce the translocation of Nrf2 to cell nucleus and activate the expression of cytoprotective genes encoding for HO-1 and NQO-1.
It suggests that ginger oleoresin has a potential role of being an effective antioxidant and radioprotective agent.
American Psychological Association (APA)
Ji, Kaihua& Fang, Lianying& Zhao, Hui& Li, Qing& Shi, Yang& Xu, Chang…[et al.]. 2017. Ginger Oleoresin Alleviated γ-Ray Irradiation-Induced Reactive Oxygen Species via the Nrf2 Protective Response in Human Mesenchymal Stem Cells. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193825
Modern Language Association (MLA)
Ji, Kaihua…[et al.]. Ginger Oleoresin Alleviated γ-Ray Irradiation-Induced Reactive Oxygen Species via the Nrf2 Protective Response in Human Mesenchymal Stem Cells. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1193825
American Medical Association (AMA)
Ji, Kaihua& Fang, Lianying& Zhao, Hui& Li, Qing& Shi, Yang& Xu, Chang…[et al.]. Ginger Oleoresin Alleviated γ-Ray Irradiation-Induced Reactive Oxygen Species via the Nrf2 Protective Response in Human Mesenchymal Stem Cells. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193825
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193825